PREDICTING PATIENTS’ TREATMENT RESPONSE TO NON SURGICAL PERIODONTAL TREATMENT WITH SUBGINGIVAL LIPOPOLYSACCHARIDE: A PROSPECTIVE PILOT STUDY

Abstract

Lipopolysaccharide (LPS) is a key virulence factor of gram-negative bacteria and it has been implicated in the pathogenesis of periodontitis. Current clinical parameters such as periodontal probing depth (PPD) or full-mouth bleeding score (FMBS) may not accurately predict the treatment response after non-surgical periodontal therapy (NSPT) due to their inherent limitations. This study aims to evaluate if the amounts of LPS in subgingival plaque can be used to predict treatment outcome at a patient level. Lipopolysaccharide (LPS) is a key virulence factor of gram-negative bacteria and it has been implicated in the pathogenesis of periodontitis. Current clinical parameters such as periodontal probing depth (PPD) or full-mouth bleeding score (FMBS) may not accurately predict the treatment response after non-surgical periodontal therapy (NSPT) due to their inherent limitations. This study aims to evaluate if the amounts of LPS in subgingival plaque can be used to predict treatment outcome at a patient level. Lipopolysaccharide (LPS) is a key virulence factor of gram-negative bacteria and it has been implicated in the pathogenesis of periodontitis. Current clinical parameters such as periodontal probing depth (PPD) or full-mouth bleeding score (FMBS) may not accurately predict the treatment response after non-surgical periodontal therapy (NSPT) due to their inherent limitations. This study aims to evaluate if the amounts of LPS in subgingival plaque can be used to predict treatment outcome at a patient level. Lipopolysaccharide (LPS) is a key virulence factor of gram-negative bacteria and it has been implicated in the pathogenesis of periodontitis. Current clinical parameters such as periodontal probing depth (PPD) or full-mouth bleeding score (FMBS) may not accurately predict the treatment response after non-surgical periodontal therapy (NSPT) due to their inherent limitations. This study aims to evaluate if the amounts of LPS in subgingival plaque can be used to predict treatment outcome at a patient level. Lipopolysaccharide (LPS) is a key virulence factor of gram-negative bacteria and it has been implicated in the pathogenesis of periodontitis. Current clinical parameters such as periodontal probing depth (PPD) or full-mouth bleeding score (FMBS) may not accurately predict the treatment response after non-surgical periodontal therapy (NSPT) due to their inherent limitations. This study aims to evaluate if the amounts of LPS in subgingival plaque can be used to predict treatment outcome at a patient level. Lipopolysaccharide (LPS) is a key virulence factor of gram-negative bacteria and it has been implicated in the pathogenesis of periodontitis. Current clinical parameters such as periodontal probing depth (PPD) or full-mouth bleeding score (FMBS) may not accurately predict the treatment response after non-surgical periodontal therapy (NSPT) due to their inherent limitations. This study aims to evaluate if the amounts of LPS in subgingival plaque can be used to predict treatment outcome at a patient level.