Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.molcel.2020.04.014
| Title: | Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria | Authors: | Tan, Yong Zi Zhang, Lei Rodrigues, Jose Zheng, Ruixiang Blake Giacometti, Sabrina Rosario, Ana L Kloss, Brian Dandey, Venkata P Wei, Hui Brunton, Richard Raczkowski, Ashleigh M Athayde, Diogo Catalao, Maria Joao Pimentel, Madalena Clarke, Oliver B Lowary, Todd L Archer, Margarida Niederweis, Michael Potter, Clinton S Carragher, Bridget Mancia, Filippo |
Keywords: | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Cell Biology ACYL CARRIER PROTEIN WALL ARABINAN BIOSYNTHESIS TUBERCULOSIS CELL-WALL PHOSPHATIDYLINOSITOL MANNOSIDE N-GLYCOSYLATION MOLECULAR-BASIS IDENTIFICATION ARABINOGALACTAN MEMBRANE MODEL |
Issue Date: | 21-May-2020 | Publisher: | CELL PRESS | Citation: | Tan, Yong Zi, Zhang, Lei, Rodrigues, Jose, Zheng, Ruixiang Blake, Giacometti, Sabrina, Rosario, Ana L, Kloss, Brian, Dandey, Venkata P, Wei, Hui, Brunton, Richard, Raczkowski, Ashleigh M, Athayde, Diogo, Catalao, Maria Joao, Pimentel, Madalena, Clarke, Oliver B, Lowary, Todd L, Archer, Margarida, Niederweis, Michael, Potter, Clinton S, Carragher, Bridget, Mancia, Filippo (2020-05-21). Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria. MOLECULAR CELL 78 (4) : 683-+. ScholarBank@NUS Repository. https://doi.org/10.1016/j.molcel.2020.04.014 | Abstract: | Tan et al. present the cryo-EM structures of essential wild-type and mutant mycobacterial arabinofuranosyltransferase D (AftD), revealing the putative active site geometry and carbohydrate-binding modules. Acyl carrier protein (ACP) was tightly associated with AftD. Impairing ACP binding blocks AftD's active site, suggesting that ACP regulates enzyme function. | Source Title: | MOLECULAR CELL | URI: | https://scholarbank.nus.edu.sg/handle/10635/227202 | ISSN: | 10972765 10974164 |
DOI: | 10.1016/j.molcel.2020.04.014 |
| Appears in Collections: | Staff Publications Elements |
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| File | Description | Size | Format | Access Settings | Version | |
|---|---|---|---|---|---|---|
| 2020-05-07_Tan_MolecularCell.pdf | Published version | 7.42 MB | Adobe PDF | CLOSED | None |
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