Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms23042375
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dc.titleThe Gut-Skin Microbiota Axis and Its Role in Diabetic Wound Healing-A Review Based on Current Literature
dc.contributor.authorPatel, Bharati Kadamb
dc.contributor.authorPatel, Kadamb Haribhai
dc.contributor.authorHuang, Ryan Yuki
dc.contributor.authorLee, Chuen Neng
dc.contributor.authorMoochhala, Shabbir M
dc.date.accessioned2022-06-14T03:39:24Z
dc.date.available2022-06-14T03:39:24Z
dc.date.issued2022-02-01
dc.identifier.citationPatel, Bharati Kadamb, Patel, Kadamb Haribhai, Huang, Ryan Yuki, Lee, Chuen Neng, Moochhala, Shabbir M (2022-02-01). The Gut-Skin Microbiota Axis and Its Role in Diabetic Wound Healing-A Review Based on Current Literature. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 (4). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms23042375
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/227082
dc.description.abstractDiabetic foot ulcers (DFU) are a growing concern worldwide as they pose complications in routine clinical practices such as diagnosis and management. Bacterial interactions on the skin surface are vital to the pathophysiology of DFU and may control delayed wound healing. The microbiota from our skin directly regulates cutaneous health and disease by interacting with the numerous cells involved in the wound healing mechanism. Commensal microbiota, in particular, interact with wound-repairing skin cells to enhance barrier regeneration. The observed microbes in DFU include Staphylococcus, Streptococcus, Corynebacterium, Pseudomonas, and several anaerobes. Skin commensal microbes, namely S. epidermidis, can regulate the gamma delta T cells and induce Perforin-2 expression. The increased expression of Perforin-2 by skin cells destroyed S. aureus within the cells, facilitating wound healing. Possible crosstalk between the human commensal microbiome and different cell types involved in cutaneous wound healing promotes the immune response and helps to maintain the barrier function in humans. Wound healing is a highly well-coordinated, complex mechanism; it can be devastating if interrupted. Skin microbiomes are being studied in relation to the gut-skin axis along with their effects on dermatologic conditions. The gut-skin axis illustrates the connection wherein the gut can impact skin health due to its immunological and metabolic properties. The precise mechanism underlying gut-skin microbial interactions is still unidentified, but the immune and endocrine systems are likely to be involved. Next-generation sequencing and the development of bioinformatics pipelines may considerably improve the understanding of the microbiome-skin axis involved in diabetic wound healing in a much more sophisticated way. We endeavor to shed light on the importance of these pathways in the pathomechanisms of the most prevalent inflammatory conditions including the diabetes wound healing, as well as how probiotics may intervene in the gut-skin axis.
dc.language.isoen
dc.publisherMDPI
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPhysical Sciences
dc.subjectBiochemistry & Molecular Biology
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry
dc.subjectmicrobiota
dc.subjectdysbiosis
dc.subjectprobiotics
dc.subjectdiabetes
dc.subjectwound healing
dc.subjectINNATE IMMUNE-RESPONSE
dc.subjectCLINICAL-PRACTICE
dc.subjectEPITHELIAL-CELLS
dc.subjectBARRIER FUNCTION
dc.subjectPROBIOTICS
dc.subjectINFECTION
dc.subjectBACTERIA
dc.subjectDIVERSITY
dc.subjectPATHOGENS
dc.subjectGROWTH
dc.typeArticle
dc.date.updated2022-06-14T02:55:47Z
dc.contributor.departmentDEPT OF SURGERY
dc.contributor.departmentBIOLOGY (NU)
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.3390/ijms23042375
dc.description.sourcetitleINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
dc.description.volume23
dc.description.issue4
dc.published.statePublished
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