Please use this identifier to cite or link to this item: https://doi.org/10.1097/SHK.0000000000001654
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dc.titleGut Microbiota Dysbiosis as a Target for Improved Post-Surgical Outcomes and Improved Patient Care: A Review of Current Literature
dc.contributor.authorMustansir Dawoodbhoy, Fatema
dc.contributor.authorPatel, Bharati Kadamb
dc.contributor.authorPatel, Kadamb
dc.contributor.authorBhatia, Madhav
dc.contributor.authorLee, Chuen Neng
dc.contributor.authorMoochhala, Shabbir M
dc.date.accessioned2022-06-14T02:58:14Z
dc.date.available2022-06-14T02:58:14Z
dc.date.issued2021-04-01
dc.identifier.citationMustansir Dawoodbhoy, Fatema, Patel, Bharati Kadamb, Patel, Kadamb, Bhatia, Madhav, Lee, Chuen Neng, Moochhala, Shabbir M (2021-04-01). Gut Microbiota Dysbiosis as a Target for Improved Post-Surgical Outcomes and Improved Patient Care: A Review of Current Literature. SHOCK 55 (4) : 441-454. ScholarBank@NUS Repository. https://doi.org/10.1097/SHK.0000000000001654
dc.identifier.issn1073-2322
dc.identifier.issn1540-0514
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/227076
dc.description.abstractABSTRACT: Critical illness results in significant changes in the human gut microbiota, leading to the breakdown of the intestinal barrier function, which plays a role in the pathogenesis of multiple organ dysfunction. Patients with sepsis/acute respiratory distress syndrome (ARDS) have a profoundly distorted intestinal microbiota rhythm, which plays a considerable role in the development of gut-derived infections and intestinal dysbiosis. Despite recent medical developments, postsurgical complications are associated with a high morbidity and mortality rate. Bacterial translocation, which is the movement of bacteria and bacterial products across the intestinal barrier, was shown to be a mechanism behind sepsis. Current research is focusing on a solution by addressing significant factors that contribute to intestinal dysbiosis, which subsequently leads to multiple organ failure and, thus, mortality. It may, however, be challenging to manipulate the microbiota in critically ill patients for enhanced therapeutic gain. Probiotic manipulation is advantageous for maintaining the gut-barrier defense and for modulating the immune response. Based on available published research, this review aims to address the application of potential strategies in the intensive care unit, supplemented with current therapeutics by the administration of probiotics, prebiotics, and fecal microbiota transplant, to reduce post-surgical complications of sepsis/ARDS in critically ill patients.
dc.language.isoen
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectCritical Care Medicine
dc.subjectHematology
dc.subjectSurgery
dc.subjectPeripheral Vascular Disease
dc.subjectGeneral & Internal Medicine
dc.subjectCardiovascular System & Cardiology
dc.subjectAcute respiratory distress syndrome
dc.subjectbacterial translocation
dc.subjectfecal microbiota transplant
dc.subjectgut dysbiosis
dc.subjectgut microbiota
dc.subjectprebiotics
dc.subjectprobiotics
dc.subjectsepsis
dc.subjectVENTILATOR-ASSOCIATED PNEUMONIA
dc.subjectLUNG MICROBIOME
dc.subjectBACTERIAL TRANSLOCATION
dc.subjectPOSTOPERATIVE COMPLICATIONS
dc.subjectSEPTIC COMPLICATIONS
dc.subjectSEPSIS
dc.subjectTRANSPLANTATION
dc.subjectMECHANISMS
dc.subjectDISEASE
dc.subjectFLORA
dc.typeReview
dc.date.updated2022-06-14T02:50:18Z
dc.contributor.departmentBIOLOGY (NU)
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.contributor.departmentDEPT OF SURGERY
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1097/SHK.0000000000001654
dc.description.sourcetitleSHOCK
dc.description.volume55
dc.description.issue4
dc.description.page441-454
dc.published.statePublished
dc.description.redepositcompleted
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