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Title: Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation
Authors: King, Charlotte
McKenna, Amanda
Farzan, Niloufar
Vijverberg, Susanne J
van der Schee, Marc P
Maitland-van der Zee, Anke H
Arianto, Lambang
Bisgaard, Hans
Bonnelykke, Klaus
Berce, Vojko
Potocnik, Uros
Repnik, Katja
Carleton, Bruce
Daley, Denise
Chew, Fook Tim 
Chiang, Wen Chin 
Sio, Yang Yie 
Cloutier, Michelle M
Den Dekker, Herman T
Duijts, Liesbeth
de Jongste, Johan C
Dijk, F Nicole
Koppelman, Gerard H
Flores, Carlos
Hernandez-Pacheco, Natalia
Pino-Yanes, Maria
Mukhopadhyay, Somnath
Basu, Kaninika
Bignell, Lauren
Tantisira, Kelan G
Turner, Steve
Verhamme, Katia M
Francis, Ben
Pirmohamed, Munir
Sinha, Ian
Hawcutt, Daniel B
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
Pharmacology & Pharmacy
Issue Date: 17-Jan-2020
Citation: King, Charlotte, McKenna, Amanda, Farzan, Niloufar, Vijverberg, Susanne J, van der Schee, Marc P, Maitland-van der Zee, Anke H, Arianto, Lambang, Bisgaard, Hans, Bonnelykke, Klaus, Berce, Vojko, Potocnik, Uros, Repnik, Katja, Carleton, Bruce, Daley, Denise, Chew, Fook Tim, Chiang, Wen Chin, Sio, Yang Yie, Cloutier, Michelle M, Den Dekker, Herman T, Duijts, Liesbeth, de Jongste, Johan C, Dijk, F Nicole, Koppelman, Gerard H, Flores, Carlos, Hernandez-Pacheco, Natalia, Pino-Yanes, Maria, Mukhopadhyay, Somnath, Basu, Kaninika, Bignell, Lauren, Tantisira, Kelan G, Turner, Steve, Verhamme, Katia M, Francis, Ben, Pirmohamed, Munir, Sinha, Ian, Hawcutt, Daniel B (2020-01-17). Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation. PHARMACOGENOMICS JOURNAL 20 (5) : 621-628. ScholarBank@NUS Repository.
Abstract: A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy.
ISSN: 1470-269X
DOI: 10.1038/s41397-019-0140-y
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