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Title: Defining skin aging and its risk factors: a systematic review and meta-analysis
Authors: Wong, QYA 
Chew, FT 
Keywords: Age Factors
Air Pollutants
Air Pollution
Risk Factors
Sex Factors
Skin Aging
Ultraviolet Rays
Issue Date: 1-Dec-2021
Publisher: Springer Science and Business Media LLC
Citation: Wong, QYA, Chew, FT (2021-12-01). Defining skin aging and its risk factors: a systematic review and meta-analysis. Scientific Reports 11 (1) : 22075-. ScholarBank@NUS Repository.
Abstract: Skin aging has been defined to encompass both intrinsic and extrinsic aging, with extrinsic aging effected by environmental influences and overlaying the effects of chronological aging. The risk factors of skin aging have been studied previously, using methods of quantifying skin aging. However, these studies have yet to be reviewed. To better understand skin aging risk factors and collate the available data, we aimed to conduct a systematic review and meta-analysis. We conducted our systematic review in compliance with Preferred Reporting Item for Systematic Review and Meta-Analyses (PRISMA) guidelines. Embase, PubMed and Web of Science databases were searched in October 2020 using specific search strategies. Where odds ratios were reported, meta-analyses were conducted using the random effects model. Otherwise, significant factors were reported in this review. We identified seven notable risk factors for various skin aging phenotypes: age, gender, ethnicity, air pollution, nutrition, smoking, sun exposure. This review’s results will guide future works, such as those aiming to examine the interaction between genetic and environmental influences.
Source Title: Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-021-01573-z
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