Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/226822
Title: Potential Implications of Mitochondrial Unfolded Protein Response in the Pathogenesis and Therapy of Dopaminergic Neuron Degeneration in Parkinson’s Disease.
Authors: Zhou, Zhidong 
Chao, Yin Xia
Tan, Eng King 
Keywords: Degeneration
Dopamine
Mitochondria
Pathogenesis
Parkinson’s disease
Therapy
Unfold protein response
Issue Date: 28-Mar-2017
Publisher: SciMedCenter
Citation: Zhou, Zhidong, Chao, Yin Xia, Tan, Eng King (2017-03-28). Potential Implications of Mitochondrial Unfolded Protein Response in the Pathogenesis and Therapy of Dopaminergic Neuron Degeneration in Parkinson’s Disease.. JSM Biotechnol Bioeng 4 (1) : 1075-1079. ScholarBank@NUS Repository.
Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. The mitochondria dysfunction has long been appreciated in PD pathogenesis and can be the common pathological pathway contributing to dopaminergic (DA) neuron degeneration in PD. However mitochondria have its own quality control (QC) defensive systems to protect against stresses induced mitochondria impairment and cell degeneration. The mitochondrial QC system includes cellular QC and molecular QC systems. The mitochondrial cellular QC system includes mitophagy, mitofusion and mitofission processes. The mitochondria molecular QC system mainly refers to mitochondria unfolded protein response (mtUPR), including stress induced activation of expression of nucleus encoded mitochondria chaperones and proteases, which can be sent back to mitochondria to counteract against stress induced mitochondria impairment. So far little is known about mtUPR signaling pathway and its relevance to human diseases. The disturbance of mtUPR can be the cause for genetic factors as well as environmental factors induced mitochondria impairment and DA neuron degeneration in PD. The screening and identification of novel small molecular weight neuroprotective mtUPR activators can help develop future anti-PD drugs to alleviate progressive DA neuron degeneration in PD. Furthermore novel molecular targets identified in mtUPR signaling pathway and the potential crosstalk between mtUPR and PD relevant genes can add to PD pathogenesis and therapy. In this short review, these issues will be analyzed and discussed.
Source Title: JSM Biotechnol Bioeng
URI: https://scholarbank.nus.edu.sg/handle/10635/226822
ISSN: 2333-7117
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