Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12968-020-0598-4
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dc.titleThe application of exercise stress cardiovascular magnetic resonance in patients with suspected dilated cardiomyopathy
dc.contributor.authorThu-Thao, Le
dc.contributor.authorBryant, Jennifer Ann
dc.contributor.authorAng, Briana Wei Yin
dc.contributor.authorPua, Chee Jian
dc.contributor.authorSu, Boyang
dc.contributor.authorHo, Pei Yi
dc.contributor.authorLim, Shiqi
dc.contributor.authorHuang, Weiting
dc.contributor.authorLee, Phong Teck
dc.contributor.authorTang, Hak Chiaw
dc.contributor.authorChin, Chee Tang
dc.contributor.authorTan, Boon Yew
dc.contributor.authorCook, Stuart Alexander
dc.contributor.authorChin, Calvin Woon-Loong
dc.date.accessioned2022-06-07T09:18:04Z
dc.date.available2022-06-07T09:18:04Z
dc.date.issued2020-02-03
dc.identifier.citationThu-Thao, Le, Bryant, Jennifer Ann, Ang, Briana Wei Yin, Pua, Chee Jian, Su, Boyang, Ho, Pei Yi, Lim, Shiqi, Huang, Weiting, Lee, Phong Teck, Tang, Hak Chiaw, Chin, Chee Tang, Tan, Boon Yew, Cook, Stuart Alexander, Chin, Calvin Woon-Loong (2020-02-03). The application of exercise stress cardiovascular magnetic resonance in patients with suspected dilated cardiomyopathy. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE 22 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12968-020-0598-4
dc.identifier.issn1097-6647
dc.identifier.issn1532-429X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/226664
dc.description.abstractObjectives: The imaging features of dilated cardiomyopathy (DCM) overlap with physiological exercise-induced cardiac remodeling in active and otherwise healthy individuals. Distinguishing the two conditions is challenging. This study examined the diagnostic and prognostic roles of exercise stress imaging in asymptomatic patients with suspected DCM. Methods: Exercise stress cardiovascular magnetic resonance (CMR) was performed in 60 asymptomatic patients with suspected DCM (dilated left ventricle and/or impaired systolic function on CMR), who also underwent DNA sequencing for DCM-causing genetic variants. Confirmed DCM was defined as genotype- and phenotype-positive (G+P+). Another 100 healthy subjects were recruited to establish normal exercise capacities (peak exercise cardiac index; PeakCI). The primary outcome was a composite of all-cause mortality, cardiac decompensation and ventricular arrhythmic events. Results: No patients with confirmed G+P+ DCM had PeakCI exceeding the 35th percentile specific for age and sex. Applying this threshold in G-P+ patients, those with PeakCI below 35th percentile had characteristics similar to confirmed DCM while patients with higher PeakCI were younger, more active and higher longitudinal strain. Adverse cardiovascular events occurred only in patients with low exercise capacity (P = 0.004). Conclusions: In individuals with suspected DCM, exercise stress CMR demonstrates diagnostic and prognostic potential in distinguishing between pathological DCM and physiological exercise-induced cardiac remodeling.
dc.language.isoen
dc.publisherBMC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectCardiac & Cardiovascular Systems
dc.subjectRadiology, Nuclear Medicine & Medical Imaging
dc.subjectCardiovascular System & Cardiology
dc.subjectCardiovascular magnetic resonance
dc.subjectSupine bike ergometer
dc.subjectExercise induced cardiac remodeling
dc.subjectDilated cardiomyopathy
dc.subjectHEART
dc.subjectASSOCIATION
dc.subjectSTATEMENT
dc.subjectMORTALITY
dc.subjectFIBROSIS
dc.subjectDEATH
dc.typeArticle
dc.date.updated2022-06-07T01:41:38Z
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentDEPT OF SURGERY
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.description.doi10.1186/s12968-020-0598-4
dc.description.sourcetitleJOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
dc.description.volume22
dc.description.issue1
dc.published.statePublished
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