Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.ejmech.2019.111597
DC Field | Value | |
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dc.title | Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells | |
dc.contributor.author | Tan, Yu-Jia | |
dc.contributor.author | Ali, Azhar | |
dc.contributor.author | Tee, Sheng-Yang | |
dc.contributor.author | Teo, Jun-Ting | |
dc.contributor.author | Xi, Yu | |
dc.contributor.author | Go, Mei-Lin | |
dc.contributor.author | Lam, Yulin | |
dc.date.accessioned | 2022-06-07T09:14:38Z | |
dc.date.available | 2022-06-07T09:14:38Z | |
dc.date.issued | 2020-03-11 | |
dc.identifier.citation | Tan, Yu-Jia, Ali, Azhar, Tee, Sheng-Yang, Teo, Jun-Ting, Xi, Yu, Go, Mei-Lin, Lam, Yulin (2020-03-11). Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 182. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejmech.2019.111597 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.issn | 1768-3254 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/226660 | |
dc.description.abstract | Fatty acid synthase (FASN) is a lipogenic enzyme that is selectively upregulated in malignant cells. There is growing consensus on the oncogenicity of FASN-driven lipogenesis and the potential of FASN as a druggable target in cancer. Here, we report the synthesis and FASN inhibitory activities of two novel galloyl esters of trans-stilbene EC1 and EC5. Inhibition of FASN was accompanied by a loss in AKT activation and profound apoptosis in several non-small cell lung cancer (NSCLC) cells at the growth inhibitory concentrations of EC1 and EC5. Both FASN and phospho-AKT levels were concurrently downregulated. However, addition of a lipid concentrate to the treated cells reinstated cell viability and reversed the loss of FASN and AKT protein levels, thus recapitulating the causal relationship between FASN inhibition and the loss in cell viability. | |
dc.language.iso | en | |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Chemistry, Medicinal | |
dc.subject | Pharmacology & Pharmacy | |
dc.subject | FASN inhibitors | |
dc.subject | Anticancer | |
dc.subject | Galloyl esters of trans-stilbenes | |
dc.subject | Non-small cell lung cancer | |
dc.subject | EGCG | |
dc.subject | FATTY-ACID SYNTHASE | |
dc.subject | EPIGALLOCATECHIN GALLATE | |
dc.subject | NATURAL INHIBITOR | |
dc.subject | OVEREXPRESSION | |
dc.subject | POLYPHENOLS | |
dc.subject | ACTIVATION | |
dc.subject | APOPTOSIS | |
dc.subject | PATHWAY | |
dc.subject | KINASE | |
dc.subject | GROWTH | |
dc.type | Article | |
dc.date.updated | 2022-06-07T01:36:31Z | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.contributor.department | DEPT OF CHEMISTRY | |
dc.contributor.department | DEPT OF PHARMACY | |
dc.description.doi | 10.1016/j.ejmech.2019.111597 | |
dc.description.sourcetitle | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | |
dc.description.volume | 182 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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2019 EJMC_GML.pdf | 2.45 MB | Adobe PDF | CLOSED | None |
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