Please use this identifier to cite or link to this item: https://doi.org/10.1186/s40101-021-00273-x
Title: Risk factors of asthma in the Asian population: a systematic review and meta-analysis
Authors: Sio, Yang Yie 
Chew, Fook Tim 
Keywords: Science & Technology
Life Sciences & Biomedicine
Physiology
Asthma
Review
Risk
Meta-analysis
OUTDOOR AIR-POLLUTION
BODY-MASS INDEX
SELF-REPORTED ASTHMA
TOKOROZAWA CHILDHOOD ASTHMA
5TH GRADE SCHOOLCHILDREN
BREAST-FEEDING DURATION
PRIMARY-SCHOOL CHILDREN
ALLERGIC DISEASES
RESPIRATORY SYMPTOMS
PRESCHOOL-CHILDREN
Issue Date: 9-Dec-2021
Publisher: BMC
Citation: Sio, Yang Yie, Chew, Fook Tim (2021-12-09). Risk factors of asthma in the Asian population: a systematic review and meta-analysis. JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY 40 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s40101-021-00273-x
Abstract: Background and objective: An increasing trend of asthma prevalence was observed in Asia; however, contributions of environmental and host-related risk factors to the development of this disease remain uncertain. This study aimed to perform a systematic review and meta-analysis for asthma-associated risk factors reported in Asia. Methods: We systematically searched three public databases (Web of Science, PubMed, and Scopus) in Feb 2021. We only included articles that reported environmental and host-related risk factors associated with asthma in the Asian population. Random-effect meta-analyses were conducted for frequently reported asthma-associated risk factors to provide an overall risk estimate of asthma development. Results: Of 4030 records obtained from public databases, 289 articles were selected for review. The most frequently reported asthma-associated risk factor was the family history of allergy-related conditions. The random-effect asthma risk estimates (pooled odds ratio, OR) were 4.66 (95% confidence interval (CI): 3.73–5.82) for the family history of asthma, 3.50 (95% CI: 2.62–4.67) for the family history of atopy, 3.57 (95% CI: 3.03–4.22) for the family history of any allergic diseases, 1.96 (95% CI: 1.47–2.61) for the family history of allergic rhinitis, and 2.75 (95% CI: 1.12–6.76) for the family history of atopic dermatitis. For housing-related factors, including the presence of mold, mold spots, mold odor, cockroach, water damage, and incense burning, the random-effect pooled OR ranged from 1.43 to 1.73. Other risk factors with significant pooled OR for asthma development included male gender (1.30, 95% CI: 1.23–1.38), cigarette smoke exposure (1.44, 95% CI: 1.30–1.60), cigarette smoking (1.66, 95% CI: 1.44–1.90), body mass index (BMI)–related parameters (pooled OR ranged from 1.06 to 2.02), various types of air pollution (NO2, PM10, and O3; pooled OR ranged from 1.03 to 1.22), and pre- and perinatal factors (low birth weight, preterm birth, and cesarean section; pooled OR ranged from 1.14 to 1.32). Conclusions: The family history of asthma was the most frequently reported risk factor for asthma development in Asia with the highest risk estimate for asthma development. This suggests a major role of the genetic component in asthma pathogenesis. Further study on asthma genetics is required to improve the current understanding of asthma etiology.
Source Title: JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/226587
ISSN: 1880-6805
DOI: 10.1186/s40101-021-00273-x
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