Please use this identifier to cite or link to this item: https://doi.org/10.1126/sciadv.abj4641
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dc.titleTransitional premonocytes emerge in the periphery for host defense against bacterial infections
dc.contributor.authorTeh, Ye Chean
dc.contributor.authorChooi, Ming Yao
dc.contributor.authorLiu, Dehua
dc.contributor.authorKwok, Immanuel
dc.contributor.authorLai, Ghee Chuan
dc.contributor.authorYong, Liyana Ayub Ow
dc.contributor.authorNg, Melissa
dc.contributor.authorLi, Jackson LY
dc.contributor.authorTan, Yingrou
dc.contributor.authorEvrard, Maximilien
dc.contributor.authorTan, Leonard
dc.contributor.authorLiong, Ka Hang
dc.contributor.authorLeong, Keith
dc.contributor.authorGoh, Chi Ching
dc.contributor.authorChan, Andrew YJ
dc.contributor.authorShadan, Nurhidaya Binte
dc.contributor.authorMantri, Chinmay Kumar
dc.contributor.authorHwang, You Yi
dc.contributor.authorCheng, Hui
dc.contributor.authorCheng, Tao
dc.contributor.authorYu, Weimiao
dc.contributor.authorTey, Hong Liang
dc.contributor.authorLarbi, Anis
dc.contributor.authorSt John, Ashley
dc.contributor.authorAngeli, Veronique
dc.contributor.authorRuedl, Christiane
dc.contributor.authorLee, Bernett
dc.contributor.authorGinhoux, Florent
dc.contributor.authorChen, Swaine L
dc.contributor.authorNg, Lai Guan
dc.contributor.authorDing, Jeak Ling
dc.contributor.authorChong, Shu Zhen
dc.date.accessioned2022-06-02T04:51:30Z
dc.date.available2022-06-02T04:51:30Z
dc.date.issued2022-03-01
dc.identifier.citationTeh, Ye Chean, Chooi, Ming Yao, Liu, Dehua, Kwok, Immanuel, Lai, Ghee Chuan, Yong, Liyana Ayub Ow, Ng, Melissa, Li, Jackson LY, Tan, Yingrou, Evrard, Maximilien, Tan, Leonard, Liong, Ka Hang, Leong, Keith, Goh, Chi Ching, Chan, Andrew YJ, Shadan, Nurhidaya Binte, Mantri, Chinmay Kumar, Hwang, You Yi, Cheng, Hui, Cheng, Tao, Yu, Weimiao, Tey, Hong Liang, Larbi, Anis, St John, Ashley, Angeli, Veronique, Ruedl, Christiane, Lee, Bernett, Ginhoux, Florent, Chen, Swaine L, Ng, Lai Guan, Ding, Jeak Ling, Chong, Shu Zhen (2022-03-01). Transitional premonocytes emerge in the periphery for host defense against bacterial infections. SCIENCE ADVANCES 8 (9). ScholarBank@NUS Repository. https://doi.org/10.1126/sciadv.abj4641
dc.identifier.issn23752548
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/226356
dc.description.abstractCirculating Ly6Chi monocytes often undergo cellular death upon exhaustion of their antibacterial effector functions, which limits their capacity for subsequent macrophage differentiation. This shrouds the understanding on how the host replaces the tissue-resident macrophage niche effectively during bacterial invasion to avert infection morbidity. Here, we show that proliferating transitional premonocytes (TpMos), an immediate precursor of mature Ly6Chi monocytes (MatMos), were mobilized into the periphery in response to acute bacterial infection and sepsis. TpMos were less susceptible to apoptosis and served as the main source of macrophage replenishment when MatMos were vulnerable toward bacteria-induced cellular death. Furthermore, TpMo and its derived macrophages contributed to host defense by balancing the proinflammatory cytokine response of MatMos. Consequently, adoptive transfer of TpMos improved the survival outcome of lethal sepsis. Our findings hence highlight a protective role for TpMos during bacterial infections and their contribution toward monocyte-derived macrophage heterogeneity in distinct disease outcomes.
dc.language.isoen
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE
dc.sourceElements
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectCOLONY-STIMULATING FACTOR
dc.subjectTRANSFER-RNA SYNTHETASE
dc.subjectBONE-MARROW
dc.subjectMONOCYTE EMIGRATION
dc.subjectESCHERICHIA-COLI
dc.subjectMACROPHAGES
dc.subjectSURVIVAL
dc.subjectCELLS
dc.subjectLIVER
dc.subjectIDENTIFICATION
dc.typeArticle
dc.date.updated2022-06-02T04:44:10Z
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentDEPT OF BIOLOGICAL SCIENCES
dc.contributor.departmentDEPT OF CHEMICAL & BIOMOLECULAR ENGG
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF MICROBIOLOGY & IMMUNOLOGY
dc.contributor.departmentDUKE-NUS OFFICE OF ACAD & CLINICAL DEVT
dc.description.doi10.1126/sciadv.abj4641
dc.description.sourcetitleSCIENCE ADVANCES
dc.description.volume8
dc.description.issue9
dc.published.statePublished
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