Please use this identifier to cite or link to this item: https://doi.org/10.1126/sciadv.abj4641
Title: Transitional premonocytes emerge in the periphery for host defense against bacterial infections
Authors: Teh, Ye Chean
Chooi, Ming Yao
Liu, Dehua
Kwok, Immanuel
Lai, Ghee Chuan
Yong, Liyana Ayub Ow 
Ng, Melissa
Li, Jackson LY
Tan, Yingrou
Evrard, Maximilien
Tan, Leonard
Liong, Ka Hang 
Leong, Keith
Goh, Chi Ching 
Chan, Andrew YJ
Shadan, Nurhidaya Binte
Mantri, Chinmay Kumar 
Hwang, You Yi
Cheng, Hui
Cheng, Tao
Yu, Weimiao
Tey, Hong Liang 
Larbi, Anis 
St John, Ashley 
Angeli, Veronique 
Ruedl, Christiane
Lee, Bernett
Ginhoux, Florent 
Chen, Swaine L 
Ng, Lai Guan 
Ding, Jeak Ling 
Chong, Shu Zhen
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
COLONY-STIMULATING FACTOR
TRANSFER-RNA SYNTHETASE
BONE-MARROW
MONOCYTE EMIGRATION
ESCHERICHIA-COLI
MACROPHAGES
SURVIVAL
CELLS
LIVER
IDENTIFICATION
Issue Date: 1-Mar-2022
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Citation: Teh, Ye Chean, Chooi, Ming Yao, Liu, Dehua, Kwok, Immanuel, Lai, Ghee Chuan, Yong, Liyana Ayub Ow, Ng, Melissa, Li, Jackson LY, Tan, Yingrou, Evrard, Maximilien, Tan, Leonard, Liong, Ka Hang, Leong, Keith, Goh, Chi Ching, Chan, Andrew YJ, Shadan, Nurhidaya Binte, Mantri, Chinmay Kumar, Hwang, You Yi, Cheng, Hui, Cheng, Tao, Yu, Weimiao, Tey, Hong Liang, Larbi, Anis, St John, Ashley, Angeli, Veronique, Ruedl, Christiane, Lee, Bernett, Ginhoux, Florent, Chen, Swaine L, Ng, Lai Guan, Ding, Jeak Ling, Chong, Shu Zhen (2022-03-01). Transitional premonocytes emerge in the periphery for host defense against bacterial infections. SCIENCE ADVANCES 8 (9). ScholarBank@NUS Repository. https://doi.org/10.1126/sciadv.abj4641
Abstract: Circulating Ly6Chi monocytes often undergo cellular death upon exhaustion of their antibacterial effector functions, which limits their capacity for subsequent macrophage differentiation. This shrouds the understanding on how the host replaces the tissue-resident macrophage niche effectively during bacterial invasion to avert infection morbidity. Here, we show that proliferating transitional premonocytes (TpMos), an immediate precursor of mature Ly6Chi monocytes (MatMos), were mobilized into the periphery in response to acute bacterial infection and sepsis. TpMos were less susceptible to apoptosis and served as the main source of macrophage replenishment when MatMos were vulnerable toward bacteria-induced cellular death. Furthermore, TpMo and its derived macrophages contributed to host defense by balancing the proinflammatory cytokine response of MatMos. Consequently, adoptive transfer of TpMos improved the survival outcome of lethal sepsis. Our findings hence highlight a protective role for TpMos during bacterial infections and their contribution toward monocyte-derived macrophage heterogeneity in distinct disease outcomes.
Source Title: SCIENCE ADVANCES
URI: https://scholarbank.nus.edu.sg/handle/10635/226356
ISSN: 23752548
DOI: 10.1126/sciadv.abj4641
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