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Title: Three dimensional modeling of atrioventricular valves provides predictive guides for optimal choice of prosthesis
Authors: Sazzad, F 
Goh, JH
Ong, ZX
Almsherqi, ZAM 
Lakshminarasappa, SR 
Ramanathan, KR 
Kofidis, T 
Keywords: Animals
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation
Mitral Valve
Mitral Valve Insufficiency
Tricuspid Valve
Issue Date: 1-Dec-2022
Publisher: Springer Science and Business Media LLC
Citation: Sazzad, F, Goh, JH, Ong, ZX, Almsherqi, ZAM, Lakshminarasappa, SR, Ramanathan, KR, Kofidis, T (2022-12-01). Three dimensional modeling of atrioventricular valves provides predictive guides for optimal choice of prosthesis. Scientific Reports 12 (1) : 7432-. ScholarBank@NUS Repository.
Abstract: Inaccuracies in intraoperative and preoperative measurements and estimations may lead to adverse outcomes such as patient-prosthesis mismatch. We aim to measure the relation between different dimensions of the atrioventricular valve complex in explanted porcine heart models. After a detailed physical morphology study, a cast of the explanted heart models was made using silicon-based materials. Digital models were obtained from three-dimensional scanning of the casts, showing the measured annulopapillary distance was 2.50 ± 0.18 cm, and 2.75 ± 0.36 cm for anterior and posterior papillary muscles of left ventricle, respectively. There was a significant linear association between the mitral annular circumference to anterior–posterior distance (p = 0.003, 95% CI 0.78–3.06), mitral annular circumference to interpapillary distance (p = 0.009, 95% CI 0.38–2.20), anterior–posterior distance to interpapillary distance (p = 0.02, 95% CI 0.10–0.78). Anterior–posterior distance appeared to be the most important predictor of mitral annular circumference compared to other measured distances. The mean length of the perpendicular distance of the tricuspid annulus, a, was 2.65 ± 0.54 cm; b was 1.77 ± 0.60 cm, and c was 3.06 ± 0.55 cm. Distance c was the most significant predictor for tricuspid annular circumference (p = 0.006, 95% CI 0.28–2.84). The anterior–posterior distance measured by three-dimensional scanning can safely be used to predict the annular circumference of the mitral valve. For the tricuspid valve, the strongest predictor for the circumference is the c-distance. Other measurements made from the positively correlated parameters may be extrapolated to their respective correlated parameters. They can aid surgeons in selecting the optimal prosthesis for the patients and improve procedural planning.
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/s41598-022-10515-2
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