Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/22527
DC Field | Value | |
---|---|---|
dc.title | Deficits in water escape performance and alterations in hippocampal cholinergic mechanisms associated with neonatal monosodium glutamate treatment in mice | |
dc.contributor.author | Wong, P.T.-H. | |
dc.contributor.author | Neo, L.H. | |
dc.contributor.author | Teo, W.L. | |
dc.contributor.author | Feng, H. | |
dc.contributor.author | Xue, Y.D. | |
dc.contributor.author | Loke, W.H. | |
dc.date.accessioned | 2011-05-10T02:37:22Z | |
dc.date.available | 2011-05-10T02:37:22Z | |
dc.date.issued | 1997 | |
dc.identifier.citation | Wong, P.T.-H., Neo, L.H., Teo, W.L., Feng, H., Xue, Y.D., Loke, W.H. (1997). Deficits in water escape performance and alterations in hippocampal cholinergic mechanisms associated with neonatal monosodium glutamate treatment in mice. Pharmacology Biochemistry and Behavior 57 (1-2) : 383-388. ScholarBank@NUS Repository. | |
dc.identifier.issn | 00913057 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/22527 | |
dc.description.abstract | Mice treated neonatally with monosodium glutamate (MSG) were found to have learning and memory deficits in performing a non-spatial water escape task. Scopolamine impaired the water-escape performance of the control mice but not that of the MSG-treated mice. It was suggested that the water- escape performance deficit in the MSG-treated mice was a result of impaired central cholinergic mechanisms. As such, scopolamine was unable to further incapacitate an already impaired cholinergic system. This is strongly supported by the decreased affinity of the sodium-dependent high-affinity choline uptake observed in the hippocampus. d-Cycloserine, a partial agonist at the glycine site of the NMDA receptor, did not affect the water-escape performance of the MSG treated and control mice; nor did it alter the effects of scopolamine. This lack of effect of d-Cycloserine may imply that the NMDA receptors are not involved in non-spatial learning. In contrast to their reported involvement in spatial learning. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0091-3057(96)00338-3 | |
dc.source | Scopus | |
dc.subject | Hippocampal cholinergic mechanisms | |
dc.subject | Learning and memory | |
dc.subject | Monosodium glutamate | |
dc.subject | NMDA receptors D-Cycloserine | |
dc.subject | Scopolamine | |
dc.subject | Water escape task | |
dc.type | Article | |
dc.contributor.department | SOCIAL WORK & PSYCHOLOGY | |
dc.description.sourcetitle | Pharmacology Biochemistry and Behavior | |
dc.description.volume | 57 | |
dc.description.issue | 1-2 | |
dc.description.page | 383-388 | |
dc.description.coden | PBBHA | |
dc.identifier.isiut | A1997XA08800053 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.