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Title: Complexation, Dynamics and Rheology of Vesicles and Polymers
Keywords: Interaction, Phospholipid Vesicles, Polymer, Concentration, Molecular Weight, Complexation
Issue Date: 4-Aug-2010
Citation: CHIENG YU YUAN (2010-08-04). Complexation, Dynamics and Rheology of Vesicles and Polymers. ScholarBank@NUS Repository.
Abstract: This thesis work is aimed to investigate and elucidate the interaction mechanisms for the mixture of phospholipid vesicles and several types of polymer with varying experimental parameters. The mixture dependence upon polymer concentration and molecular weight, phospholipid vesicles concentration, ionic strength and pH has been studied in details using a variety of techniques. Pluronic triblock copolymer molecules were inserted into the lipid bilayer at unimer state via hydrophobic interaction. For high concentrations, Pluronic F-127 forms mixed micelles with solubilized lipid molecules in the form of bilayer patches. In contrast, more hydrophobic L-61 precipitates with the solubilized lipids as large crew-cut mixed aggregates. Poly(acrylic acid) completely disrupt the bilayers of vesicles at high enough concentration and large molecular weight through hydrogen bonding interaction. For small molecular weight, the complexation leads to vesicle aggregation. Meanwhile, the presence of phospholipid vesicles as linkers within the hydrophobically modified hydroxyethylcellulose significantly enhances the system viscosity. Electrostatic interaction between Poly(diallyldimethylammonium chloride) and anionic phospholipid vesicles has also been explored and showed interesting interaction mechanisms from charge compensation, to charge neutralization and charge reversal phenomenon.
Appears in Collections:Ph.D Theses (Open)

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