Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/22126
DC Field | Value | |
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dc.title | Anti-inflammatory pharmacology of histone deacetylase inhibitors in pre-clinical models of rheumatoid arthritis | |
dc.contributor.author | CHOO QIUYI | |
dc.date.accessioned | 2011-04-30T18:01:07Z | |
dc.date.available | 2011-04-30T18:01:07Z | |
dc.date.issued | 2010-06-23 | |
dc.identifier.citation | CHOO QIUYI (2010-06-23). Anti-inflammatory pharmacology of histone deacetylase inhibitors in pre-clinical models of rheumatoid arthritis. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/22126 | |
dc.description.abstract | HDAC inhibitors have emerged as a novel class of anti-cancer agents. Their anti-rheumatic activities had been documented in various pre-clinical RA models. However, their anti-rheumatic mechanisms of action are not well elucidated. The work that was carried out for this thesis aimed to elucidate the anti-inflammatory and anti-rheumatic mechanisms of action of HDAC inhibitors. Inhibition of RASF proliferation, suppression of pro-inflammatory cytokines, chemokines and NO as well as down-regulation of angiogenesis, chemotaxis and MMPs may provide beneficial effects in RA. The aforementioned effects may be a result of CDK inhibitor p21 up-regulation as well as MAPK and NF-kappaB inhibition. Hence, HDAC inhibitors appear to be an innovative strategy for RA management. | |
dc.language.iso | en | |
dc.subject | Inflammation, Histone, Histone Deactylase, Rheumatoid arthritis, Synovial fibroblast, NF-kappaB | |
dc.type | Thesis | |
dc.contributor.department | PHARMACY | |
dc.contributor.supervisor | HO CHI LUI, PAUL | |
dc.contributor.supervisor | LIN HAISHU | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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ChooQY.pdf | 3.78 MB | Adobe PDF | OPEN | None | View/Download |
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