Please use this identifier to cite or link to this item: https://doi.org/10.1042/BSR20201707
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dc.titleA 12-week aerobic exercise intervention results in improved metabolic function and lower adipose tissue and ectopic fat in high-fat diet fed rats
dc.contributor.authorGopalan, Venkatesh
dc.contributor.authorYaligar, Jadegoud
dc.contributor.authorMichael, Navin
dc.contributor.authorKaur, Kavita
dc.contributor.authorAnantharaj, Rengaraj
dc.contributor.authorVerma, Sanjay Kumar
dc.contributor.authorSadananthan, Suresh Anand
dc.contributor.authorLe, Giang Thi Thu
dc.contributor.authorGoh, Jorming
dc.contributor.authorVelan, S Sendhil
dc.date.accessioned2022-04-21T06:17:03Z
dc.date.available2022-04-21T06:17:03Z
dc.date.issued2021-01-01
dc.identifier.citationGopalan, Venkatesh, Yaligar, Jadegoud, Michael, Navin, Kaur, Kavita, Anantharaj, Rengaraj, Verma, Sanjay Kumar, Sadananthan, Suresh Anand, Le, Giang Thi Thu, Goh, Jorming, Velan, S Sendhil (2021-01-01). A 12-week aerobic exercise intervention results in improved metabolic function and lower adipose tissue and ectopic fat in high-fat diet fed rats. BIOSCIENCE REPORTS 41 (1). ScholarBank@NUS Repository. https://doi.org/10.1042/BSR20201707
dc.identifier.issn0144-8463
dc.identifier.issn1573-4935
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/219440
dc.description.abstractInvestigations of long-term exercise interventions in humans to reverse obesity is expensive and is hampered by poor compliance and confounders. In the present study, we investigated intrahepatic and muscle fat, visceral and subcutaneous fat pads, plasma metabolic profile and skeletal muscle inflammatory markers in response to 12-week aerobic exercise in an obese rodent model. Six-week-old male Wistar rats (n=20) were randomized to chow-fed control (Control, n=5), sedentary high-fat diet (HFD, n=5), chow-fed exercise (Exercise, n=5) and HFD-fed exercise (HFD+Exercise, n=5) groups. The exercise groups were subjected to 12 weeks of motorized treadmill running at a speed of 18 m/min for 30 min/day. Differences in post-intervention measures were assessed by analysis of covariance (ANCOVA), adjusted for baseline bodyweight and pre-intervention measures, where available. Post-hoc analyses were performed with Bonferroni correction. Plasma metabolic profile was worsened and fat pads, ectopic fat in muscle and liver and inflammatory markers in skeletal muscle were elevated in sedentary HFD-fed animals relative to chow-fed controls. HFD+Exercise animals had significantly lower leptin (P=0.0004), triglycerides (P=0.007), homeostatic model assessment of insulin resistance (HOMA-IR; P=0.065), intramyocellular lipids (IMCLs; P=0.003), intrahepatic lipids (IHLs; P<0.0001), body fat% (P=0.001), subcutaneous adipose tissue (SAT; P<0.0001), visceral adipose (P<0.0001) and total fat mass (P<0.0001), relative to sedentary HFD-fed animals, despite only modestly lower bodyweight. Messenger RNA (mRNA) expression of inflammatory markers Interleukin 6 (IL6) and Tumor necrosis factor α (TNFα) were also reduced with aerobic exercise in skeletal muscle. Our results suggest that 12 weeks of aerobic exercise training is effective in improving metabolic health, fat depots, ectopic fat and inflammation even against a high-fat dietary background.
dc.language.isoen
dc.publisherPORTLAND PRESS LTD
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectBiochemistry & Molecular Biology
dc.subjectCell Biology
dc.subjectPOLYMERASE CHAIN-REACTION
dc.subjectLIFE-STYLE INTERVENTION
dc.subjectSKELETAL-MUSCLE
dc.subjectINSULIN-RESISTANCE
dc.subjectLIPID-METABOLISM
dc.subjectGENE-EXPRESSION
dc.subjectENZYME-ACTIVITY
dc.subjectLIVER-DISEASE
dc.subjectOBESITY
dc.subjectADAPTATIONS
dc.typeArticle
dc.date.updated2022-04-21T01:37:15Z
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.contributor.departmentDEPT OF OBSTETRICS & GYNAECOLOGY
dc.description.doi10.1042/BSR20201707
dc.description.sourcetitleBIOSCIENCE REPORTS
dc.description.volume41
dc.description.issue1
dc.published.statePublished
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