Please use this identifier to cite or link to this item: https://doi.org/10.2174/092986707782023280
Title: Potential therapeutic effects of exercise to the brain
Authors: Ang, ET 
Gomez-Pinilla, F
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Chemistry, Medicinal
Pharmacology & Pharmacy
exercise
neurotrophins
p75(NTR)
cytokines
learning
memory
NERVE GROWTH-FACTOR
TUMOR-NECROSIS-FACTOR
FOCAL CEREBRAL-ISCHEMIA
LONG-TERM POTENTIATION
REDUCES INFARCT SIZE
INTERLEUKIN-1 RECEPTOR ANTAGONIST
SPATIAL MEMORY IMPAIRMENTS
CHOLINERGIC NEURON ATROPHY
ACTIVATED PROTEIN-KINASE
MESSENGER-RNA EXPRESSION
Issue Date: 1-Jan-2007
Publisher: BENTHAM SCIENCE PUBL LTD
Citation: Ang, ET, Gomez-Pinilla, F (2007-01-01). Potential therapeutic effects of exercise to the brain. CURRENT MEDICINAL CHEMISTRY 14 (24) : 2564-2571. ScholarBank@NUS Repository. https://doi.org/10.2174/092986707782023280
Abstract: Exercise is a well-recognized facet of modern living; however, the threat of sedentary lifestyle is ever increasing with the arrival of the technological period. Although the beneficial effects of exercise to the health and function of the brain have been accepted by the scientific and medical community, much remains to be achieved to understand its mechanisms of action. With the advent of modern investigative tools, several more key molecular and cellular players have been implicated in the above process. Such include the family of neurotrophins (e.g. NGF and BDNF) and their receptors, some pro-inflammatory cytokines (L-1β, IL-6, TNF-α, IFN-γ), microglia and astrocytes, and the cholinergic neuronal cells in the forebrain. While experiments based on the voluntary exercise paradigm has been the preferred approach to studying the brain, less is known about the forced paradigm. We will discuss in this review how molecular players may feature differently in the context of exercise and more importantly how their actions converged to impact the structure, and function (learning and memory) of the CNS. © 2007 Bentham Science Publishers Ltd.
Source Title: CURRENT MEDICINAL CHEMISTRY
URI: https://scholarbank.nus.edu.sg/handle/10635/219292
ISSN: 09298673
1875533X
DOI: 10.2174/092986707782023280
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