Please use this identifier to cite or link to this item: https://doi.org/10.1098/rsif.2021.0631
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dc.titleThe panniculus carnosus muscle: a missing link in the chronicity of heel pressure ulcers?
dc.contributor.authorNasir, N Jannah M
dc.contributor.authorCorrias, Alberto
dc.contributor.authorHeemskerk, Hans
dc.contributor.authorAng, Eng Tat
dc.contributor.authorJenkins, Julia H
dc.contributor.authorSebastin, SJ
dc.contributor.authorTucker-Kellogg, Lisa
dc.date.accessioned2022-04-19T04:30:02Z
dc.date.available2022-04-19T04:30:02Z
dc.date.issued2022-02-23
dc.identifier.citationNasir, N Jannah M, Corrias, Alberto, Heemskerk, Hans, Ang, Eng Tat, Jenkins, Julia H, Sebastin, SJ, Tucker-Kellogg, Lisa (2022-02-23). The panniculus carnosus muscle: a missing link in the chronicity of heel pressure ulcers?. JOURNAL OF THE ROYAL SOCIETY INTERFACE 19 (187). ScholarBank@NUS Repository. https://doi.org/10.1098/rsif.2021.0631
dc.identifier.issn17425689
dc.identifier.issn17425662
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/219279
dc.description.abstractChronic and recurring pressure ulcers (PUs) create an unmet need for predictive biomarkers. In this work, we examine the panniculus carnosus, a thin cutaneous muscle, traditionally considered vestigial in humans, and ask whether the panniculus may play a role in the chronicity and reinjury of heel PUs. To determine whether humans have a panniculus muscle layer at the heel, we dissected eight cadavers. To assess the influence of the panniculus layer on PU, we performed computational simulations of supine weight bearing. Finally, we assessed panniculus regeneration in fluorescent mice. Results show a panniculus layer present in all cadavers examined. Simulations show a thin layer of panniculus muscle causes a dramatic decrease in the volume of soft tissue experiencing high strain and stress, compared to a heel without a panniculus. Importantly, in the mouse model, the panniculus fails to regenerate after PU, even when other cutaneous layers had fully regenerated. Our work shows that the panniculus is able to redistribute load around the heel bone, which might allow it to prevent PUs. Moreover, it is highly susceptible to incomplete regeneration after PU. Poor panniculus regeneration after PU might be a predictive anatomical biomarker for recurrence, and this biomarker should be evaluated prospectively in future clinical trials.
dc.language.isoen
dc.publisherROYAL SOC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectchronic wounds
dc.subjectpressure injuries
dc.subjectfunctional anatomy of heel
dc.subjectlineage tracing in mouse
dc.subjectbiomechanics of muscle
dc.subjectmuscle regeneration
dc.subjectEVIDENCE-BASED MEDICINE
dc.subjectSKIN
dc.subjectMODEL
dc.subjectPREVALENCE
dc.subjectANATOMY
dc.subjectRISK
dc.subjectCARE
dc.typeArticle
dc.date.updated2022-04-18T14:56:51Z
dc.contributor.departmentDEPT OF ANATOMY
dc.contributor.departmentDEPT OF BIOMEDICAL ENGINEERING
dc.contributor.departmentDEPT OF ORTHOPAEDIC SURGERY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1098/rsif.2021.0631
dc.description.sourcetitleJOURNAL OF THE ROYAL SOCIETY INTERFACE
dc.description.volume19
dc.description.issue187
dc.published.statePublished
dc.description.redepositcompleted
dc.description.redepositcompleted
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