Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsami.7b01462
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dc.titleCold Chain-Free Storable Hydrogel for Infant-Friendly Oral Delivery of Amoxicillin for the Treatment of Pneumococcal Pneumonia
dc.contributor.authorXu, Keming
dc.contributor.authorLi, Liang
dc.contributor.authorCui, Mingyue
dc.contributor.authorHan, Yiyuan
dc.contributor.authorKarahan, H Enis
dc.contributor.authorChow, Vincent TK
dc.contributor.authorXu, Chenjie
dc.date.accessioned2022-04-11T03:06:47Z
dc.date.available2022-04-11T03:06:47Z
dc.date.issued2017-06-07
dc.identifier.citationXu, Keming, Li, Liang, Cui, Mingyue, Han, Yiyuan, Karahan, H Enis, Chow, Vincent TK, Xu, Chenjie (2017-06-07). Cold Chain-Free Storable Hydrogel for Infant-Friendly Oral Delivery of Amoxicillin for the Treatment of Pneumococcal Pneumonia. ACS APPLIED MATERIALS & INTERFACES 9 (22) : 18440-18449. ScholarBank@NUS Repository. https://doi.org/10.1021/acsami.7b01462
dc.identifier.issn19448244
dc.identifier.issn19448252
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/218833
dc.description.abstractPneumonia is the major cause of death in children under five, particularly in developing countries. Antibiotics such as amoxicillin greatly help in mitigating this problem. However, there is a lack of an infant/toddler-friendly formulation for countries with limited clean water orr electricity. Here, we report the development of a shear-thinning hydrogel system for the oral delivery of amoxicillin to infant/toddler patients, without the need of clean water and refrigeration. The hydrogel formulation consists of metolose (hydroxypropyl methylcellulose) and amoxicillin. It preserves the structural integrity of antibiotics and their antibacterial activity over 12 weeks at room temperature. Pharmacokinetic profiling of mice reveals that the hydrogel formulation increases the bioavailability of drugs by ∼18% compared to that with aqueous amoxicillin formulation. More importantly, oral gavage of this formulation in a mouse model of secondary pneumococcal pneumonia significantly ameliorates inflammatory infiltration and tissue damage in lungs, with a 10-fold reduction in bacterial counts compared to those in untreated ones. Given the remarkable antibacterial efficacy as well as the use of FDA-regulated ingredients (metolose and amoxicillin), the hydrogel formulation holds great promise for rapid clinical translation.
dc.language.isoen
dc.publisherAMER CHEMICAL SOC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectTechnology
dc.subjectNanoscience & Nanotechnology
dc.subjectMaterials Science, Multidisciplinary
dc.subjectScience & Technology - Other Topics
dc.subjectMaterials Science
dc.subjectamoxicillin
dc.subjectshear-thinning hydrogel
dc.subjectmetolose
dc.subjectpediatric formulation
dc.subjectpneumonia
dc.subjectSTREPTOCOCCUS-PNEUMONIAE
dc.subjectPOTASSIUM CLAVULANATE
dc.subjectSTABILITY
dc.subjectMETHYLCELLULOSE
dc.subjectPH
dc.subjectPROGRESS
dc.typeArticle
dc.date.updated2022-04-08T10:30:19Z
dc.contributor.departmentDEPT OF MICROBIOLOGY & IMMUNOLOGY
dc.description.doi10.1021/acsami.7b01462
dc.description.sourcetitleACS APPLIED MATERIALS & INTERFACES
dc.description.volume9
dc.description.issue22
dc.description.page18440-18449
dc.published.statePublished
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