Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsami.7b01462
Title: Cold Chain-Free Storable Hydrogel for Infant-Friendly Oral Delivery of Amoxicillin for the Treatment of Pneumococcal Pneumonia
Authors: Xu, Keming
Li, Liang
Cui, Mingyue
Han, Yiyuan
Karahan, H Enis
Chow, Vincent TK 
Xu, Chenjie
Keywords: Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
amoxicillin
shear-thinning hydrogel
metolose
pediatric formulation
pneumonia
STREPTOCOCCUS-PNEUMONIAE
POTASSIUM CLAVULANATE
STABILITY
METHYLCELLULOSE
PH
PROGRESS
Issue Date: 7-Jun-2017
Publisher: AMER CHEMICAL SOC
Citation: Xu, Keming, Li, Liang, Cui, Mingyue, Han, Yiyuan, Karahan, H Enis, Chow, Vincent TK, Xu, Chenjie (2017-06-07). Cold Chain-Free Storable Hydrogel for Infant-Friendly Oral Delivery of Amoxicillin for the Treatment of Pneumococcal Pneumonia. ACS APPLIED MATERIALS & INTERFACES 9 (22) : 18440-18449. ScholarBank@NUS Repository. https://doi.org/10.1021/acsami.7b01462
Abstract: Pneumonia is the major cause of death in children under five, particularly in developing countries. Antibiotics such as amoxicillin greatly help in mitigating this problem. However, there is a lack of an infant/toddler-friendly formulation for countries with limited clean water orr electricity. Here, we report the development of a shear-thinning hydrogel system for the oral delivery of amoxicillin to infant/toddler patients, without the need of clean water and refrigeration. The hydrogel formulation consists of metolose (hydroxypropyl methylcellulose) and amoxicillin. It preserves the structural integrity of antibiotics and their antibacterial activity over 12 weeks at room temperature. Pharmacokinetic profiling of mice reveals that the hydrogel formulation increases the bioavailability of drugs by ∼18% compared to that with aqueous amoxicillin formulation. More importantly, oral gavage of this formulation in a mouse model of secondary pneumococcal pneumonia significantly ameliorates inflammatory infiltration and tissue damage in lungs, with a 10-fold reduction in bacterial counts compared to those in untreated ones. Given the remarkable antibacterial efficacy as well as the use of FDA-regulated ingredients (metolose and amoxicillin), the hydrogel formulation holds great promise for rapid clinical translation.
Source Title: ACS APPLIED MATERIALS & INTERFACES
URI: https://scholarbank.nus.edu.sg/handle/10635/218833
ISSN: 19448244
19448252
DOI: 10.1021/acsami.7b01462
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