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dc.titlePrediction of poor clinical outcome in vascular cognitive impairment: TRACE-VCI study
dc.contributor.authorBoomsma, JMF
dc.contributor.authorExalto, LG
dc.contributor.authorBarkhof, F
dc.contributor.authorChen, CLH
dc.contributor.authorHilal, S
dc.contributor.authorLeeuwis, AE
dc.contributor.authorPrins, ND
dc.contributor.authorSaridin, FN
dc.contributor.authorScheltens, P
dc.contributor.authorTeunissen, CE
dc.contributor.authorVerwer, JH
dc.contributor.authorWeinstein, HC
dc.contributor.authorvan der Flier, WM
dc.contributor.authorBiessels, GJ
dc.contributor.authorBenedictus, MR
dc.contributor.authorBremer, J
dc.contributor.authorLeijenaar, J
dc.contributor.authorvan Maurik, IS
dc.contributor.authorTijms, BM
dc.contributor.authorWattjes, MP
dc.contributor.authorKoene, T
dc.contributor.authorvan den Berg, E
dc.contributor.authorFerro, DA
dc.contributor.authorFrijns, CJM
dc.contributor.authorGroeneveld, ON
dc.contributor.authorHeinen, R
dc.contributor.authorvan Kalsbeek, NM
dc.contributor.authorde Bresser, J
dc.contributor.authorKuijf, HJ
dc.contributor.authorKoek, HL
dc.contributor.authorPleizier, CM
dc.contributor.authorVriens, EM
dc.contributor.authorHamaker, ME
dc.contributor.authorFaaij, RA
dc.contributor.authorVenketasubramanian, N
dc.contributor.authorVillaraza, S
dc.contributor.authorXu, X
dc.contributor.authorTan, BY
dc.identifier.citationBoomsma, JMF, Exalto, LG, Barkhof, F, Chen, CLH, Hilal, S, Leeuwis, AE, Prins, ND, Saridin, FN, Scheltens, P, Teunissen, CE, Verwer, JH, Weinstein, HC, van der Flier, WM, Biessels, GJ, Benedictus, MR, Bremer, J, Leijenaar, J, van Maurik, IS, Tijms, BM, Wattjes, MP, Koene, T, van den Berg, E, Ferro, DA, Frijns, CJM, Groeneveld, ON, Heinen, R, van Kalsbeek, NM, de Bresser, J, Kuijf, HJ, Koek, HL, Pleizier, CM, Vriens, EM, Hamaker, ME, Faaij, RA, Venketasubramanian, N, Villaraza, S, Xu, X, Tan, BY (2020-01-01). Prediction of poor clinical outcome in vascular cognitive impairment: TRACE-VCI study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 12 (1) : e12077-. ScholarBank@NUS Repository.
dc.description.abstractIntroduction: Prognostication in memory clinic patients with vascular brain injury (eg possible vascular cognitive impairment [VCI]) is often uncertain. We created a risk score to predict poor clinical outcome. Methods: Using data from two longitudinal cohorts of memory clinic patients with vascular brain injury without advanced dementia, we created (n = 707) and validated (n = 235) the risk score. Poor clinical outcome was defined as substantial cognitive decline (change of Clinical Dementia Rating ≥1 or institutionalization) or major vascular events or death. Twenty-four candidate predictors were evaluated using Cox proportional hazard models. Results: Age, clinical syndrome diagnosis, Disability Assessment for Dementia, Neuropsychiatric Inventory, and medial temporal lobe atrophy most strongly predicted poor outcome and constituted the risk score (C-statistic 0.71; validation cohort 0.78). Of note, none of the vascular predictors were retained in this model. The 2-year risk of poor outcome was 6.5% for the lowest (0-5) and 55.4% for the highest sum scores (10-13). Discussion: This is the first, validated, prediction score for 2-year clinical outcome of patients with possible VCI.
dc.subjectcognitive decline
dc.subjectmajor vascular event
dc.subjectmemory clinic
dc.subjectpoor clinical outcome
dc.subjectprediction score
dc.subjectvascular cognitive impairment
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.sourcetitleAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
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