Please use this identifier to cite or link to this item: https://doi.org/10.1002/cncr.31978
Title: Targeting autophagy using natural compounds for cancer prevention and therapy
Authors: Deng, Shuo 
Shanmugam, Muthu K 
Kumar, Alan Prem 
Yap, Celestial T 
Sethi, Gautam 
Bishayee, Anupam
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
5 '-adenosine monophosphate-activated protein kinase
autophagy-related
autophagosome
autophagy
Beclin-1
cancer
lysosome
phytochemicals
NF-KAPPA-B
REGULATED GENE-PRODUCTS
HUMAN HEPATOCELLULAR-CARCINOMA
STAT3 SIGNALING PATHWAY
HUMAN MULTIPLE-MYELOMA
DIHYDROARTEMISININ INDUCES AUTOPHAGY
ENDOPLASMIC-RETICULUM STRESS
HYPOXIA-INDUCED AUTOPHAGY
ACID-INDUCED APOPTOSIS
XENOGRAFT MOUSE MODEL
Issue Date: 15-Apr-2019
Publisher: WILEY
Citation: Deng, Shuo, Shanmugam, Muthu K, Kumar, Alan Prem, Yap, Celestial T, Sethi, Gautam, Bishayee, Anupam (2019-04-15). Targeting autophagy using natural compounds for cancer prevention and therapy. CANCER 125 (8) : 1228-1246. ScholarBank@NUS Repository. https://doi.org/10.1002/cncr.31978
Abstract: Autophagy, also known as macroautophagy, is a tightly regulated process involved in the stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation of damaged proteins and organelles in eukaryotic cells. Autophagy also plays a key role in various tissue processes and immune responses and in the regulation of inflammation. Over the past decade, three levels of autophagy regulation have been identified in mammalian cells: 1) signaling, 2) autophagosome formation, and 3) autophagosome maturation and lysosomal degradation. Any deregulation of the autophagy processes can lead to the development of diverse chronic diseases, such as diabetes, obesity, cardiovascular disease, neurodegenerative disease, and malignancies. However, the potential role of autophagy in cancer is rather complex and has been associated with both the induction and the inhibition of neoplasia. Several synthetic autophagy modulators have been identified as promising candidates for cancer therapy. In addition, diverse phytochemicals derived from natural sources, such as curcumin, ursolic acid, resveratrol, thymoquinone, and γ-tocotrienol, also have attracted attention as promising autophagy modulators with minimal side effects. In this review, the authors discuss the importance of autophagy regulators and various natural compounds that induce and/or inhibit autophagy in the prevention and therapy of cancer.
Source Title: CANCER
URI: https://scholarbank.nus.edu.sg/handle/10635/218779
ISSN: 0008543X
10970142
DOI: 10.1002/cncr.31978
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