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https://doi.org/10.1186/s13195-022-00982-0
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dc.title | A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer's disease | |
dc.contributor.author | Chua, Jacqueline | |
dc.contributor.author | Li, Chi | |
dc.contributor.author | Ho, Lucius Kang Hua | |
dc.contributor.author | Wong, Damon | |
dc.contributor.author | Tan, Bingyao | |
dc.contributor.author | Yao, Xinwen | |
dc.contributor.author | Gan, Alfred | |
dc.contributor.author | Schwarzhans, Florian | |
dc.contributor.author | Garhoefer, Gerhard | |
dc.contributor.author | Sng, Chelvin CA | |
dc.contributor.author | Hilal, Saima | |
dc.contributor.author | Venketasubramanian, Narayanaswamy | |
dc.contributor.author | Cheung, Carol Y | |
dc.contributor.author | Fischer, Georg | |
dc.contributor.author | Vass, Clemens | |
dc.contributor.author | Wong, Tien Yin | |
dc.contributor.author | Chen, Christopher Li-Hsian | |
dc.contributor.author | Schmetterer, Leopold | |
dc.date.accessioned | 2022-04-08T02:54:38Z | |
dc.date.available | 2022-04-08T02:54:38Z | |
dc.date.issued | 2022-03-10 | |
dc.identifier.citation | Chua, Jacqueline, Li, Chi, Ho, Lucius Kang Hua, Wong, Damon, Tan, Bingyao, Yao, Xinwen, Gan, Alfred, Schwarzhans, Florian, Garhoefer, Gerhard, Sng, Chelvin CA, Hilal, Saima, Venketasubramanian, Narayanaswamy, Cheung, Carol Y, Fischer, Georg, Vass, Clemens, Wong, Tien Yin, Chen, Christopher Li-Hsian, Schmetterer, Leopold (2022-03-10). A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer's disease. ALZHEIMERS RESEARCH & THERAPY 14 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s13195-022-00982-0 | |
dc.identifier.issn | 1758-9193 | |
dc.identifier.issn | 1758-9193 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/218677 | |
dc.description.abstract | Background: Diagnostic performance of optical coherence tomography (OCT) to detect Alzheimer’s disease (AD) and mild cognitive impairment (MCI) remains limited. We assessed whether compensating the circumpapillary retinal nerve fiber layer (cpRNFL) thickness for multiple demographic and anatomical factors as well as the combination of macular layers improves the detection of MCI and AD. Methods: This cross-sectional study of 62 AD (n = 92 eyes), 108 MCI (n = 158 eyes), and 55 cognitively normal control (n = 86 eyes) participants. Macular ganglion cell complex (mGCC) thickness was extracted. Circumpapillary retinal nerve fiber layer (cpRNFL) measurement was compensated for several ocular factors. Thickness measurements and their corresponding areas under the receiver operating characteristic curves (AUCs) were compared between the groups. The main outcome measure was OCT thickness measurements. Results: Participants with MCI/AD showed significantly thinner measured and compensated cpRNFL, mGCC, and altered retinal vessel density (p < 0.05). Compensated RNFL outperformed measured RNFL for discrimination of MCI/AD (AUC = 0.74 vs 0.69; p = 0.026). Combining macular and compensated cpRNFL parameters provided the best detection of MCI/AD (AUC = 0.80 vs 0.69; p < 0.001). Conclusions and relevance: Accounting for interindividual variations of ocular anatomical features in cpRNFL measurements and incorporating macular information may improve the identification of high-risk individuals with early cognitive impairment. | |
dc.language.iso | en | |
dc.publisher | BMC | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Clinical Neurology | |
dc.subject | Neurosciences | |
dc.subject | Neurosciences & Neurology | |
dc.subject | Optical coherence tomography | |
dc.subject | mild cognitive impairment | |
dc.subject | Alzheimer's disease | |
dc.subject | FIBER LAYER THICKNESS | |
dc.subject | SPECTRAL-DOMAIN OCT | |
dc.subject | AGE | |
dc.subject | SEGMENTATION | |
dc.subject | SEVERITY | |
dc.subject | PROFILE | |
dc.subject | RNFL | |
dc.type | Article | |
dc.date.updated | 2022-04-08T02:16:38Z | |
dc.contributor.department | DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.contributor.department | OPHTHALMOLOGY | |
dc.contributor.department | DEPT OF MEDICINE | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | PHARMACOLOGY | |
dc.description.doi | 10.1186/s13195-022-00982-0 | |
dc.description.sourcetitle | ALZHEIMERS RESEARCH & THERAPY | |
dc.description.volume | 14 | |
dc.description.issue | 1 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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