Please use this identifier to cite or link to this item: https://doi.org/10.1186/s13195-022-00982-0
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dc.titleA multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer's disease
dc.contributor.authorChua, Jacqueline
dc.contributor.authorLi, Chi
dc.contributor.authorHo, Lucius Kang Hua
dc.contributor.authorWong, Damon
dc.contributor.authorTan, Bingyao
dc.contributor.authorYao, Xinwen
dc.contributor.authorGan, Alfred
dc.contributor.authorSchwarzhans, Florian
dc.contributor.authorGarhoefer, Gerhard
dc.contributor.authorSng, Chelvin CA
dc.contributor.authorHilal, Saima
dc.contributor.authorVenketasubramanian, Narayanaswamy
dc.contributor.authorCheung, Carol Y
dc.contributor.authorFischer, Georg
dc.contributor.authorVass, Clemens
dc.contributor.authorWong, Tien Yin
dc.contributor.authorChen, Christopher Li-Hsian
dc.contributor.authorSchmetterer, Leopold
dc.date.accessioned2022-04-08T02:54:38Z
dc.date.available2022-04-08T02:54:38Z
dc.date.issued2022-03-10
dc.identifier.citationChua, Jacqueline, Li, Chi, Ho, Lucius Kang Hua, Wong, Damon, Tan, Bingyao, Yao, Xinwen, Gan, Alfred, Schwarzhans, Florian, Garhoefer, Gerhard, Sng, Chelvin CA, Hilal, Saima, Venketasubramanian, Narayanaswamy, Cheung, Carol Y, Fischer, Georg, Vass, Clemens, Wong, Tien Yin, Chen, Christopher Li-Hsian, Schmetterer, Leopold (2022-03-10). A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer's disease. ALZHEIMERS RESEARCH & THERAPY 14 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s13195-022-00982-0
dc.identifier.issn1758-9193
dc.identifier.issn1758-9193
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/218677
dc.description.abstractBackground: Diagnostic performance of optical coherence tomography (OCT) to detect Alzheimer’s disease (AD) and mild cognitive impairment (MCI) remains limited. We assessed whether compensating the circumpapillary retinal nerve fiber layer (cpRNFL) thickness for multiple demographic and anatomical factors as well as the combination of macular layers improves the detection of MCI and AD. Methods: This cross-sectional study of 62 AD (n = 92 eyes), 108 MCI (n = 158 eyes), and 55 cognitively normal control (n = 86 eyes) participants. Macular ganglion cell complex (mGCC) thickness was extracted. Circumpapillary retinal nerve fiber layer (cpRNFL) measurement was compensated for several ocular factors. Thickness measurements and their corresponding areas under the receiver operating characteristic curves (AUCs) were compared between the groups. The main outcome measure was OCT thickness measurements. Results: Participants with MCI/AD showed significantly thinner measured and compensated cpRNFL, mGCC, and altered retinal vessel density (p < 0.05). Compensated RNFL outperformed measured RNFL for discrimination of MCI/AD (AUC = 0.74 vs 0.69; p = 0.026). Combining macular and compensated cpRNFL parameters provided the best detection of MCI/AD (AUC = 0.80 vs 0.69; p < 0.001). Conclusions and relevance: Accounting for interindividual variations of ocular anatomical features in cpRNFL measurements and incorporating macular information may improve the identification of high-risk individuals with early cognitive impairment.
dc.language.isoen
dc.publisherBMC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectClinical Neurology
dc.subjectNeurosciences
dc.subjectNeurosciences & Neurology
dc.subjectOptical coherence tomography
dc.subjectmild cognitive impairment
dc.subjectAlzheimer's disease
dc.subjectFIBER LAYER THICKNESS
dc.subjectSPECTRAL-DOMAIN OCT
dc.subjectAGE
dc.subjectSEGMENTATION
dc.subjectSEVERITY
dc.subjectPROFILE
dc.subjectRNFL
dc.typeArticle
dc.date.updated2022-04-08T02:16:38Z
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentOPHTHALMOLOGY
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1186/s13195-022-00982-0
dc.description.sourcetitleALZHEIMERS RESEARCH & THERAPY
dc.description.volume14
dc.description.issue1
dc.published.statePublished
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