Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0224665
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dc.titleAssociation of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC).
dc.contributor.authorFong, Pei Yuan
dc.contributor.authorTan, Sze Huey
dc.contributor.authorLim, Darren Wan Teck
dc.contributor.authorTan, Eng Huat
dc.contributor.authorNg, Quan Sing
dc.contributor.authorSommat, Kiattisa
dc.contributor.authorTan, Daniel Shao Weng
dc.contributor.authorAng, Mei Kim
dc.date.accessioned2022-04-07T02:11:09Z
dc.date.available2022-04-07T02:11:09Z
dc.date.issued2019
dc.identifier.citationFong, Pei Yuan, Tan, Sze Huey, Lim, Darren Wan Teck, Tan, Eng Huat, Ng, Quan Sing, Sommat, Kiattisa, Tan, Daniel Shao Weng, Ang, Mei Kim (2019). Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC).. PLoS One 14 (11) : e0224665-. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0224665
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/218476
dc.description.abstractAIM: Treatment strategies in laryngeal squamous cell cancer (LSCC) straddle the need for long term survival and tumor control as well as preservation of laryngeal function as far as possible. We sought to identify prognostic factors affecting LSCC outcomes in our population. METHODS: Clinical characteristics, treatments and survival outcomes of patients with LSCC were analysed. Baseline comorbidity data was collected and age-adjusted Charlson Comorbidity Index (aCCI) was calculated. Outcomes of overall survival (OS), progression-free survival (PFS) and laryngectomy-free survival (LFS) were evaluated. RESULTS: Two hundred and fifteen patients were included, 170 (79%) underwent primary radiation/ chemoradiation and the remainder upfront surgery with adjuvant therapy where indicated. The majority of patients were male, Chinese and current/ex-smokers. Presence of comorbidity was common with median aCCI of 3. Median OS was 5.8 years. On multivariable analyses, high aCCI and advanced nodal status were associated with inferior OS (HR 1.24 per one point increase in aCCI, P<0.001 and HR 3.52; p<0.001 respectively), inferior PFS (HR 1.14; p = 0.007 and HR 3.23; p<0.001 respectively) and poorer LFS (HR 1.19; p = 0.001 and HR 2.95; p<0.001 respectively). Higher tumor (T) stage was associated with inferior OS and LFS (HR 1.61; p = 0.02 and HR 1.91; p = 0.01 respectively). CONCLUSION: In our Asian population, the presence of comorbidities and high nodal status were associated with inferior OS, PFS and LFS whilst high T stage was associated with inferior LFS and OS.
dc.publisherPublic Library of Science (PLoS)
dc.sourceElements
dc.subjectAdult
dc.subjectAge Factors
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectChemoradiotherapy, Adjuvant
dc.subjectComorbidity
dc.subjectFemale
dc.subjectHumans
dc.subjectKaplan-Meier Estimate
dc.subjectLaryngeal Neoplasms
dc.subjectLaryngectomy
dc.subjectLarynx
dc.subjectLymphatic Metastasis
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoadjuvant Therapy
dc.subjectNeoplasm Staging
dc.subjectOrgan Sparing Treatments
dc.subjectPrognosis
dc.subjectProgression-Free Survival
dc.subjectRetrospective Studies
dc.subjectSingapore
dc.subjectSquamous Cell Carcinoma of Head and Neck
dc.typeArticle
dc.date.updated2022-04-07T02:07:27Z
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentDUKE-NUS OFFICE OF ACAD & CLINICAL DEVT
dc.description.doi10.1371/journal.pone.0224665
dc.description.sourcetitlePLoS One
dc.description.volume14
dc.description.issue11
dc.description.pagee0224665-
dc.published.stateUnpublished
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