Please use this identifier to cite or link to this item:
https://doi.org/10.1080/23723556.2021.2007028
| Title: | A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops) | Authors: | Xavier Renaudin Ashok R. Venkitaraman |
Keywords: | BRCA2 cancer genomic instability mitochondria mtDNA replication neurodegeneration Oxidative stress PRPF8 R-loops RNA-DNA hybrid SETX |
Issue Date: | 14-Dec-2021 | Publisher: | Taylor & Francis | Citation: | Xavier Renaudin, Ashok R. Venkitaraman (2021-12-14). A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops). Molecular & Cellular Oncology 8 (6) : 3-Jan. ScholarBank@NUS Repository. https://doi.org/10.1080/23723556.2021.2007028 | Abstract: | How oxidative stress promotes aging-related human diseases like cancer and neurodegeneration remains unclear. Here, we discuss the origins and implications of an oxidative-stress response recently reported to destabilize the mitochondrial (mt) genome via unscheduled RNA/DNA hybrid (R-loop) accumulation, by impairing the recruitment of RNAseH1 to the regulatory regions of mtDNA. | Source Title: | Molecular & Cellular Oncology | URI: | https://scholarbank.nus.edu.sg/handle/10635/215761 | ISSN: | 2372-3556 | DOI: | 10.1080/23723556.2021.2007028 |
| Appears in Collections: | Staff Publications Elements |
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| 10.108023723556.2021.2007028.zip | 730.36 kB | ZIP | OPEN | None | View/Download |
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