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Please use this identifier to cite or link to this item: https://doi.org/10.1080/23723556.2021.2007028
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dc.titleA mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops)
dc.contributor.authorXavier Renaudin
dc.contributor.authorAshok R. Venkitaraman
dc.date.accessioned2022-02-21T09:17:54Z
dc.date.available2022-02-21T09:17:54Z
dc.date.issued2021-12-14
dc.identifier.citationXavier Renaudin, Ashok R. Venkitaraman (2021-12-14). A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops). Molecular & Cellular Oncology 8 (6) : 3-Jan. ScholarBank@NUS Repository. https://doi.org/10.1080/23723556.2021.2007028
dc.identifier.issn2372-3556
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/215761
dc.description.abstractHow oxidative stress promotes aging-related human diseases like cancer and neurodegeneration remains unclear. Here, we discuss the origins and implications of an oxidative-stress response recently reported to destabilize the mitochondrial (mt) genome via unscheduled RNA/DNA hybrid (R-loop) accumulation, by impairing the recruitment of RNAseH1 to the regulatory regions of mtDNA.
dc.publisherTaylor & Francis
dc.sourceTaylor & Francis
dc.subjectBRCA2
dc.subjectcancer
dc.subjectgenomic instability
dc.subjectmitochondria
dc.subjectmtDNA replication
dc.subjectneurodegeneration
dc.subjectOxidative stress
dc.subjectPRPF8
dc.subjectR-loops
dc.subjectRNA-DNA hybrid
dc.subjectSETX
dc.typeOthers
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentDEPT OF MEDICINE
dc.description.doi10.1080/23723556.2021.2007028
dc.description.sourcetitleMolecular & Cellular Oncology
dc.description.volume8
dc.description.issue6
dc.description.page3-Jan
dc.published.statePublished
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