Please use this identifier to cite or link to this item: https://doi.org/10.1080/23723556.2021.2007028
Title: A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops)
Authors: Xavier Renaudin
Ashok R. Venkitaraman 
Keywords: BRCA2
cancer
genomic instability
mitochondria
mtDNA replication
neurodegeneration
Oxidative stress
PRPF8
R-loops
RNA-DNA hybrid
SETX
Issue Date: 14-Dec-2021
Publisher: Taylor & Francis
Citation: Xavier Renaudin, Ashok R. Venkitaraman (2021-12-14). A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops). Molecular & Cellular Oncology 8 (6) : 3-Jan. ScholarBank@NUS Repository. https://doi.org/10.1080/23723556.2021.2007028
Abstract: How oxidative stress promotes aging-related human diseases like cancer and neurodegeneration remains unclear. Here, we discuss the origins and implications of an oxidative-stress response recently reported to destabilize the mitochondrial (mt) genome via unscheduled RNA/DNA hybrid (R-loop) accumulation, by impairing the recruitment of RNAseH1 to the regulatory regions of mtDNA.
Source Title: Molecular & Cellular Oncology
URI: https://scholarbank.nus.edu.sg/handle/10635/215761
ISSN: 2372-3556
DOI: 10.1080/23723556.2021.2007028
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