Please use this identifier to cite or link to this item: https://doi.org/10.1093/jn/nxaa414
Title: Branched-Chain Amino Acid Supplementation Does Not Preserve Lean Mass or Affect Metabolic Profile in Adults with Overweight or Obesity in a Randomized Controlled Weight Loss Intervention
Authors: Ooi, Delicia SQ 
Ling, Jennifer QR
Sadananthan, Suresh Anand 
Velan, S Sendhil
Ong, Fang Yi
Khoo, Chin Meng 
Tai, E Shyong 
Henry, Christiani Jeyakumar 
Leow, Melvin KS 
Khoo, Eric YH 
Tan, Chuen Seng 
Lee, Yung Seng 
Chong, Mary FF 
Keywords: Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
BCAA supplementation
weight loss
hypocaloric diet
lean mass preservation
overweight
obese
muscle mass
high-protein
Issue Date: 1-Apr-2021
Publisher: OXFORD UNIV PRESS
Citation: Ooi, Delicia SQ, Ling, Jennifer QR, Sadananthan, Suresh Anand, Velan, S Sendhil, Ong, Fang Yi, Khoo, Chin Meng, Tai, E Shyong, Henry, Christiani Jeyakumar, Leow, Melvin KS, Khoo, Eric YH, Tan, Chuen Seng, Lee, Yung Seng, Chong, Mary FF (2021-04-01). Branched-Chain Amino Acid Supplementation Does Not Preserve Lean Mass or Affect Metabolic Profile in Adults with Overweight or Obesity in a Randomized Controlled Weight Loss Intervention. JOURNAL OF NUTRITION 151 (4) : 911-920. ScholarBank@NUS Repository. https://doi.org/10.1093/jn/nxaa414
Abstract: Background: Branched-chain amino acid (BCAA) supplementation has been shown to increase muscle mass or prevent muscle loss during weight loss. Objective: We aimed to investigate the effects of a BCAA-supplemented hypocaloric diet on lean mass preservation and insulin sensitivity. Methods: A total of 132 Chinese adults (63 men and 69 women aged 21-45 y, BMI 25-36 kg/m2) were block randomly assigned by gender and BMI into 3 hypocaloric diet (deficit of 500 kcal/d) groups: standard-protein (14%) with placebo (control, CT) or BCAA supplements at 0.1 g · kg-1 body weight · d-1 (BCAA) or high-protein (27%) with placebo (HP). The subjects underwent 16 wk of dietary intervention with provision of meals and supplements, followed by 8 wk of weight maintenance with provision of supplements only. One-way ANOVA analysis was conducted to analyze the primary (lean mass and insulin sensitivity) and secondary outcomes (anthropometric and metabolic parameters) among the 3 groups. Paired t-test was used to analyze the change in each group. Results: The 3 groups demonstrated similar significant reductions in body weight (7.97%), fat mass (13.8%), and waist circumference (7.27%) after 16 wk of energy deficit. Lean mass loss in BCAA (4.39%) tended to be lower than in CT (5.39%) and higher compared with HP (3.67%) (P = 0.06). Calf muscle volume increased 3.4% in BCAA and intramyocellular lipids (IMCLs) decreased in BCAA (17%) and HP (18%) (P < 0.05) over 16 wk. During the 8 wk weight maintenance period, lean mass gain in BCAA (1.03%) tended to be lower compared with CT (1.58%) and higher than in HP (-0.002%) (P = 0.04). Lean mass gain differed significantly between CT and HP (P = 0.03). Insulin sensitivity and metabolic profiles did not differ among the groups throughout the study period. Conclusions: BCAA supplementation does not preserve lean mass or affect insulin sensitivity in overweight and obese adults during weight loss. A higher protein diet may be more advantageous for lean mass preservation.
Source Title: JOURNAL OF NUTRITION
URI: https://scholarbank.nus.edu.sg/handle/10635/215637
ISSN: 0022-3166
1541-6100
DOI: 10.1093/jn/nxaa414
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