Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00109-021-02160-5
Title: Androgen-dependent tissue factor pathway inhibitor regulating protein: a review of its peripheral actions and association with cardiometabolic diseases
Authors: Kee, Zizheng
Ong, Sze Min
Heng, Chew-Kiat 
Ooi, Delicia Shu Qin 
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
Medicine, Research & Experimental
Research & Experimental Medicine
ADTRP
TFPI
Coagulation
FAHFA hydrolase
CORONARY-ARTERY-DISEASE
PROLIFERATOR-ACTIVATED-RECEPTOR
GENOME-WIDE ASSOCIATION
CHROMOSOME 6P24.1
ATHEROSCLEROSIS
OBESITY
GENE
EXPRESSION
INFLAMMATION
Issue Date: 19-Nov-2021
Publisher: SPRINGER HEIDELBERG
Citation: Kee, Zizheng, Ong, Sze Min, Heng, Chew-Kiat, Ooi, Delicia Shu Qin (2021-11-19). Androgen-dependent tissue factor pathway inhibitor regulating protein: a review of its peripheral actions and association with cardiometabolic diseases. JOURNAL OF MOLECULAR MEDICINE-JMM 100 (2) : 185-196. ScholarBank@NUS Repository. https://doi.org/10.1007/s00109-021-02160-5
Abstract: The first genome-wide association study on coronary artery disease (CAD) in the Han Chinese population identified C6orf105 as a susceptibility gene. The C6orf105 gene was later found to encode for a protein that regulates tissue factor pathway inhibitor (TFPI) expression in endothelial cells in an androgen-dependent manner, and the novel protein was thus termed androgen-dependent TFPI-regulating protein (ADTRP). Since the identification of ADTRP, there have been several studies associating genetic variants on the ADTRP gene with CAD risk, as well as research providing mechanistic insights on this novel protein and its functional role. ADTRP is a membrane protein, whose expression is upregulated by androgen, GATA-binding protein 2, oxidized low-density lipoprotein, peroxisome proliferator‐activated receptors, and low-density lipoprotein receptors. ADTRP regulates multiple downstream targets involved in coagulation, inflammation, endothelial function, and vascular integrity. In addition, ADTRP functions as a fatty acid esters of hydroxy fatty acid (FAHFA)-specific hydrolase that is involved in energy metabolism. Current evidence suggests that ADTRP may play a role in the pathogenesis of atherosclerosis, CAD, obesity, and metabolic disorders. This review summarizes the current literature on ADTRP, with a focus on the peripheral actions of ADTRP, including expression, genetic variations, signaling pathways, and function. The evidence linking ADTRP and cardiometabolic diseases will also be discussed.
Source Title: JOURNAL OF MOLECULAR MEDICINE-JMM
URI: https://scholarbank.nus.edu.sg/handle/10635/215636
ISSN: 0946-2716
1432-1440
DOI: 10.1007/s00109-021-02160-5
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