Please use this identifier to cite or link to this item: https://doi.org/10.1002/sstr.202100118
Title: Photothermal‐Activatable Liposome Carrying Tissue Plasminogen Activator for Photoacoustic Image‐Guided Ischemic Stroke Treatment
Authors: Cai, Xiaolei 
Bandla, Aishwarya 
Wang, Can 
Liu, Yu-Hang 
Chuan, Chan Kim 
Xu, Yu
Liu, Xingang 
Xu, Shidang 
Wu, Wenbo 
Thakor, Nitish V 
Liu, Bin 
Issue Date: Feb-2022
Publisher: Wiley
Citation: Cai, Xiaolei, Bandla, Aishwarya, Wang, Can, Liu, Yu-Hang, Chuan, Chan Kim, Xu, Yu, Liu, Xingang, Xu, Shidang, Wu, Wenbo, Thakor, Nitish V, Liu, Bin (2022-02). Photothermal‐Activatable Liposome Carrying Tissue Plasminogen Activator for Photoacoustic Image‐Guided Ischemic Stroke Treatment. Small Structures 3 (2) : 2100118-2100118. ScholarBank@NUS Repository. https://doi.org/10.1002/sstr.202100118
Abstract: Ischemic stroke is a highly prevalent cause of mortality and morbidity. The only FDAapproved treatment is thrombolysis using tissue plasminogen activator (tPA), which possesses a short effective time window. Real-time recanalization monitoring is crucial to establish successful reperfusion and serves as a strong predictor of clinical outcomes. First-line clinical imaging techniques, such as computed tomography and magnetic resonance imaging, are limited in their soft-tissue resolution, scanning speed, and accessibility. Transcranial Doppler Ultrasound, the current gold standard for recanalization monitoring, is a blind technique and highly-operator dependent. Herein, we designed a photothermal-activatable liposome carrying tPA for photoacoustic (PA) image-guided therapy for real-time and precise recanalization monitoring of ischemic stroke. The liposome containing an organic molecule with propeller structures exhibits excellent photothermal properties and significantly amplified PA signals as compared to the widely used polymer nanoparticles. Near-infrared (NIR) laser triggered rapid release of tPA for quick blood clot lysis in vitro. Administration of the liposome in a rat photothrombotic ischemia model facilitated high-resolution PA imaging for precise real-time recanalization assessment. Precisely controlled tPA release at the ischemic region was achieved by PA image-guided NIR laser irradiation, which successfully dissolved the blood clot and restored perfusion, making this design promising for translational applications.
Source Title: Small Structures
URI: https://scholarbank.nus.edu.sg/handle/10635/215478
ISSN: 2688-4062
DOI: 10.1002/sstr.202100118
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