Please use this identifier to cite or link to this item: https://doi.org/10.1002/advs.202004379
Title: Light-Driven Cascade Mitochondria-to-Nucleus Photosensitization in Cancer Cell Ablation
Authors: Wang, Kang-Nan
Liu, Liu-Yi
Qi, Guobin 
Chao, Xi-Juan
Ma, Wen
Yu, Zhiqiang
Pan, Qiling
Mao, Zong-Wan
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
functional iridium complex
mitochondria&#8208
to&#8208
nucleus translocation
nucleic acid damage
photodynamic therapy
RED FLUORESCENT-PROBES
IRIDIUM(III) COMPLEX
ANTICANCER
METABOLISM
Issue Date: 8-Feb-2021
Publisher: WILEY
Citation: Wang, Kang-Nan, Liu, Liu-Yi, Qi, Guobin, Chao, Xi-Juan, Ma, Wen, Yu, Zhiqiang, Pan, Qiling, Mao, Zong-Wan, Liu, Bin (2021-02-08). Light-Driven Cascade Mitochondria-to-Nucleus Photosensitization in Cancer Cell Ablation. ADVANCED SCIENCE 8 (8). ScholarBank@NUS Repository. https://doi.org/10.1002/advs.202004379
Abstract: Nuclei and mitochondria are the only cellular organelles containing genes, which are specific targets for efficient cancer therapy. So far, several photosensitizers have been reported for mitochondria targeting, and another few have been reported for nuclei targeting. However, none have been reported for photosensitization in both mitochondria and nucleus, especially in cascade mode, which can significantly reduce the photosensitizers needed for maximal treatment effect. Herein, a light-driven, mitochondria-to-nucleus cascade dual organelle cancer cell ablation strategy is reported. A functionalized iridium complex, named BT-Ir, is designed as a photosensitizer, which targets mitochondria first for photosensitization and subsequently is translocated to a cell nucleus for continuous photodynamic cancer cell ablation. This strategy opens new opportunities for efficient photodynamic therapy.
Source Title: ADVANCED SCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/215106
ISSN: 2198-3844,2198-3844
DOI: 10.1002/advs.202004379
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