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Title: Polypoidal choroidal vasculopathy: outer retinal and choroidal changes and neovascularization development in the fellow eye
Authors: Baek, J.
Cheung, C.M.G. 
Jeon, S.
Lee, J.H.
Lee, W.K.
Keywords: Fellow eye study
Polypoidal choroidal vasculopathy
Rpe changes
Issue Date: 2019
Publisher: Association for Research in Vision and Ophthalmology Inc.
Citation: Baek, J., Cheung, C.M.G., Jeon, S., Lee, J.H., Lee, W.K. (2019). Polypoidal choroidal vasculopathy: outer retinal and choroidal changes and neovascularization development in the fellow eye. Investigative Ophthalmology and Visual Science 60 (2) : 590-598. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: PURPOSE. We investigated the outer retinal, RPE, and choroidal changes and the development of choroidal neovascularization (CNV) in fellow eyes of patients with unilateral polypoidal choroidal vasculopathy or aneurysmal type 1 neovascularization (PCV/AT1). METHODS. In this retrospective observational cohort study, 263 patients with unilateral PCV/ AT1 were enrolled. Fundus photography, enhanced depth imaging optical coherence tomography, and indocyanine green angiography at baseline and follow-up were analyzed. Incidence and risk factors for the development of CNV were analyzed. RESULTS. In fellow eyes of unilateral PCV/AT1 cases, RPE and outer retinal abnormalities were observed in 222 (84%) eyes, and dilated Haller vessels (pachyvessel) were identified in the corresponding abnormality area in 157 (71%) eyes. Follow-up data were available for 233 patients. During a 27.6-month mean follow-up period, 20/233 (9%) eyes had CNV (12 PCV/ AT1 and eight type 1 CNV). In 18 eyes (90%), CNV developed at the RPE or outer retinal abnormality areas accompanied by pachyvessel. A significantly higher risk for CNV was observed if RPE and outer retinal abnormalities were accompanied by pachyvessel (hazard ratio, 9.3; 95% confidence interval, 1.1-75.9, P = 0.037). CONCLUSIONS. RPE and outer retinal abnormalities were common in fellow eyes of patients presenting with unilateral PCV/AT1. CNV developed in fellow eyes of 9% of patients, frequently in the areas with RPE and outer retinal abnormality accompanied by pachyvessel. © 2019 The Authors.
Source Title: Investigative Ophthalmology and Visual Science
ISSN: 0146-0404
DOI: 10.1167/iovs.18-24244
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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