Please use this identifier to cite or link to this item:
https://doi.org/10.1093/nar/gky1207
DC Field | Value | |
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dc.title | Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1 | |
dc.contributor.author | Lin, L. | |
dc.contributor.author | Huang, M. | |
dc.contributor.author | Shi, X. | |
dc.contributor.author | Mayakonda, A. | |
dc.contributor.author | Hu, K. | |
dc.contributor.author | Jiang, Y.-Y. | |
dc.contributor.author | Guo, X. | |
dc.contributor.author | Chen, L. | |
dc.contributor.author | Pang, B. | |
dc.contributor.author | Doan, N. | |
dc.contributor.author | Said, J.W. | |
dc.contributor.author | Xie, J. | |
dc.contributor.author | Gery, S. | |
dc.contributor.author | Cheng, X. | |
dc.contributor.author | Lin, Z. | |
dc.contributor.author | Li, J. | |
dc.contributor.author | Berman, B.P. | |
dc.contributor.author | Yin, D. | |
dc.contributor.author | Lin, D.-C. | |
dc.contributor.author | Koeffler, H.P. | |
dc.date.accessioned | 2022-01-11T06:18:52Z | |
dc.date.available | 2022-01-11T06:18:52Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Lin, L., Huang, M., Shi, X., Mayakonda, A., Hu, K., Jiang, Y.-Y., Guo, X., Chen, L., Pang, B., Doan, N., Said, J.W., Xie, J., Gery, S., Cheng, X., Lin, Z., Li, J., Berman, B.P., Yin, D., Lin, D.-C., Koeffler, H.P. (2019). Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. Nucleic Acids Research 47 (3) : 1255-12567. ScholarBank@NUS Repository. https://doi.org/10.1093/nar/gky1207 | |
dc.identifier.issn | 0305-1048 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/213709 | |
dc.description.abstract | As the second most common malignant bone tumor in children and adolescents, Ewing sarcoma is initiated and exacerbated by a chimeric oncoprotein, most commonly, EWS-FLI1. In this study, we apply epigenomic analysis to characterize the transcription dysregulation in this cancer, focusing on the investigation of super-enhancer and its associated transcriptional regulatory mechanisms. We demonstrate that super-enhancer-associated transcripts are significantly enriched in EWS-FLI1 target genes, contribute to the aberrant transcriptional network of the disease, and mediate the exceptional sensitivity of Ewing sarcoma to transcriptional inhibition. Through integrative analysis, we identify MEIS1 as a super-enhancer-driven oncogene, which co-operates with EWS-FLI1 in transcriptional regulation, and plays a key pro-survival role in Ewing sarcoma. Moreover, APCDD1, another super-enhancer associated gene, acting as a downstream target of both MEIS1 and EWS-FLI1, is also characterized as a novel tumor-promoting factor in this malignancy. These data delineate super-enhancer-mediated transcriptional deregulation in Ewing sarcoma, and uncover numerous candidate oncogenes which can be exploited for further understanding of the molecular pathogenesis for this disease. © The Author(s) 2018. | |
dc.publisher | Oxford University Press | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Scopus OA2019 | |
dc.type | Article | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1093/nar/gky1207 | |
dc.description.sourcetitle | Nucleic Acids Research | |
dc.description.volume | 47 | |
dc.description.issue | 3 | |
dc.description.page | 1255-12567 | |
dc.published.state | Unpublished | |
Appears in Collections: | Staff Publications Elements |
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