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Title: Dissolving Triamcinolone-Embedded Microneedles for the Treatment of Keloids: A Single-Blinded Intra-Individual Controlled Clinical Trial
Authors: Tan, C.W.X.
Tan, W.D.
Srivastava, R.
Yow, A.P.
Wong, D.W.K.
Tey, H.L. 
Keywords: Keloids
Issue Date: 2019
Publisher: Springer Healthcare
Citation: Tan, C.W.X., Tan, W.D., Srivastava, R., Yow, A.P., Wong, D.W.K., Tey, H.L. (2019). Dissolving Triamcinolone-Embedded Microneedles for the Treatment of Keloids: A Single-Blinded Intra-Individual Controlled Clinical Trial. Dermatology and Therapy 9 (3) : 601-611. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial 4.0 International
Abstract: Introduction: Keloids are a prevalent chronic skin disorder with significant psychosocial morbidity. Intralesional corticosteroid injections are the first-line treatment but are painful and require repeated injections by medical professionals. Dissolving microneedles are a novel method of cutaneous drug delivery that induces minimal/no pain and can be self-administered. The objective of the study was to evaluate the efficacy and safety of triamcinolone-embedded dissolving microneedles in treatment of keloids. Methods: This was a single-blind, intra-individual controlled two-phase clinical trial of 8-week duration each. Two keloids per subject were selected for (1) once-daily 2-min application with microneedles for 4爓eeks, followed by no treatment for the next 4爓eeks, or (2) non-intervention as control. Primary outcome was change in keloid volume as assessed by a high-resolution 3D scanner. Results: There was significant reduction in keloid volume compared with controls after 4爓eeks of treatment. This reduction was greater with a higher dosage of triamcinolone used. Conclusions: Once-daily application of dissolving triamcinolone-embedded microneedles significantly reduced the volume of keloids. The treatment was safe, can be self-administered and can serve as an alternative for patients unsuitable for conventional treatments. Trial Registration: Trial Registry: Health Science Authority (Singapore) Clinical Trials Register Registration number: 2015/00440. � 2019, The Author(s).
Source Title: Dermatology and Therapy
ISSN: 21938210
DOI: 10.1007/s13555-019-00316-3
Rights: Attribution-NonCommercial 4.0 International
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