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Title: Maternal HBeAg positivity and viremia associated with umbilical cord blood hepatitis B viremia
Authors: Lee, L.Y. 
Lee, G.H. 
Mattar, C. 
Saw, S.
Aw, M. 
Keywords: cord blood hepatitis B viral (HBV) DNA
hepatitis B core antibody
in-utero exposure to HBV
maternal hepatitis B viral (HBV) DNA
Issue Date: 2019
Publisher: Elsevier (Singapore) Pte Ltd
Citation: Lee, L.Y., Lee, G.H., Mattar, C., Saw, S., Aw, M. (2019). Maternal HBeAg positivity and viremia associated with umbilical cord blood hepatitis B viremia. Pediatrics and Neonatology 60 (5) : 517-522. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Background: Hepatitis B (HBV) transmission may result from in utero transmission. We aimed to determine the correlation between maternal serum and umbilical cord blood HBV DNA levels in infants delivered by chronic HBV-infected mothers and to describe the effect of cord blood viremia on vertical transmission. Methods: A prospective cohort of 92 chronic HBV-infected mother-and-child pairs recruited over three years was analyzed. Maternal and cord blood were tested for HBV DNA by real-time PCR. Standard immunoprophylaxis with both active and passive immunization was administered to all infants. Serological testing was performed on all infants at 9 months of age. Results: Moderate positive correlation of the maternal HBV DNA with cord blood HBV DNA was demonstrated (r2 = 0.521, p = <0.001). HBeAg +ve mothers were younger with higher HBV and cord viremia. At 9 months of age, one infant was infected. Infants delivered by HBeAg positive mothers and mothers with high HBV DNA of more than 6 LOG IU/mL (1 x 106 IU/mL) have increased relative risk of cord blood viremia. Conclusions: Maternal HBV DNA and presence of HBeAg were positively correlated to cord blood HBV DNA in infants delivered by chronic HBV-infected mothers. Our data suggest that reducing maternal viremia during the antenatal period may help to reduce cord blood viremia. � 2019
Source Title: Pediatrics and Neonatology
ISSN: 18759572
DOI: 10.1016/j.pedneo.2019.01.002
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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