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Title: An appraisal of developments in Allium sulfur chemistry: Expanding the pharmacopeia of garlic
Authors: Rose, P.
Moore, P.K. 
Whiteman, M.
Zhu, Y.-Z.
Keywords: Allium
Gaseous mediators
Hydrogen sulfide
Sulfur compounds
Issue Date: 2019
Publisher: MDPI AG
Citation: Rose, P., Moore, P.K., Whiteman, M., Zhu, Y.-Z. (2019). An appraisal of developments in Allium sulfur chemistry: Expanding the pharmacopeia of garlic. Molecules 24 (21) : 4006. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Alliums and allied plant species are rich sources of sulfur compounds that have effects on vascular homeostasis and the control of metabolic systems linked to nutrient metabolism in mammals. In view of the multiple biological effects ascribed to these sulfur molecules, researchers are now using these compounds as inspiration for the synthesis and development of novel sulfur-based therapeutics. This research has led to the chemical synthesis and biological assessment of a diverse array of sulfur compounds representative of derivatives of S-alkenyl-l-cysteine sulfoxides, thiosulfinates, ajoene molecules, sulfides, and S-allylcysteine. Many of these synthetic derivatives have potent antimicrobial and anticancer properties when tested in preclinical models of disease. Therefore, the current review provides an overview of advances in the development and biological assessment of synthetic analogs of allium-derived sulfur compounds. © 2019 by the authors.
Source Title: Molecules
ISSN: 14203049
DOI: 10.3390/molecules24214006
Rights: Attribution 4.0 International
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