Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/212713
Title: INVESTIGATING SOMATOSTATIN NEURONS IN MOUSE TUBERAL NUCLEUS IN FEEDING REGULATION
Authors: ESRA SENOL
ORCID iD:   orcid.org/0000-0003-4878-0520
Keywords: feeding regulation, hypothalamus, high-fat, somatostatin, tuberal nucleus
Issue Date: 21-Jul-2021
Citation: ESRA SENOL (2021-07-21). INVESTIGATING SOMATOSTATIN NEURONS IN MOUSE TUBERAL NUCLEUS IN FEEDING REGULATION. ScholarBank@NUS Repository.
Abstract: Food intake is critical for the survival and is tightly regulated by mammalian brains, also its dysregulation leads to eating disorders. In my thesis, I investigated the hypothalamic tuberal nucleus somatostatin (TNSST) neuronal population in feeding regulation, particularly in high fat diet (HFD)-related mechanisms. Exploration of neuronal dynamics of TNSST by in vivo imaging together with genetic and viral manipulations on TNSST neurons revealed a unique HFD-specific function. Further, mapping brain-wide connections of TNSST neurons suggested an integrative role. The findings in this study highlight how TNSST neurons may integrate complex information to regulate feeding behaviour, particularly HFD-related mechanisms.
URI: https://scholarbank.nus.edu.sg/handle/10635/212713
Appears in Collections:Ph.D Theses (Open)

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