Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/212695
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dc.titleTHE INTERPLAY OF PFKP AND AMPK IN METABOLIC STRESS IN LUNG CANCER
dc.contributor.authorCHEN JIAQING
dc.date.accessioned2021-12-31T18:00:57Z
dc.date.available2021-12-31T18:00:57Z
dc.date.issued2021-08-18
dc.identifier.citationCHEN JIAQING (2021-08-18). THE INTERPLAY OF PFKP AND AMPK IN METABOLIC STRESS IN LUNG CANCER. ScholarBank@NUS Repository.
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/212695
dc.description.abstractCancer cells adopt flexible metabolic phenotypes to promote cell survival under metabolic stress conditions. A key regulator of cell metabolism is AMP-activated kinase (AMPK) which promotes catabolic while suppresses anabolic metabolism. However, the function of AMPK in metabolic stress in cancer cells remains largely undefined. In this study, we performed a proteomics screening of AMPK-interacting proteins in non-small-cell lung cancer (NSCLC) cells and discovered a glycolysis enzyme named the platelet isoform of phosphofructokinase 1 (PFKP). Importantly, PFKP was found to be highly expressed in lung adenocarcinoma and correlated with poor prognosis. We also demonstrated that the PFKP-AMPK interaction was greatly enhanced upon glucose starvation in NSCLC. Of note, this interaction promoted the mitochondrial recruitment of AMPK which subsequently phosphorylated acetyl-CoA carboxylase 2 to upregulate long-chain fatty acid oxidation. The consumption of long-chain fatty acids maintained the energy and redox balance, and thereafter promoted cancer cell survival.
dc.language.isoen
dc.subjectPFKP, AMPK, metabolism, lung cancer
dc.typeThesis
dc.contributor.departmentINTEGRATIVE SCIENCES & ENGINEERING PROG
dc.contributor.supervisorReshma Taneja
dc.contributor.supervisorOng Choon Nam
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY (NUSGS)
Appears in Collections:Ph.D Theses (Restricted)

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