Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/212678
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dc.titleFUNCTIONALIZATION OF ARYL CHLORIDES AND PYRIDINE N-oxides ENABLED BY ORGANOPHOTOCATALYSIS
dc.contributor.authorXU JINHUI
dc.date.accessioned2021-12-31T18:00:30Z
dc.date.available2021-12-31T18:00:30Z
dc.date.issued2021-08-10
dc.identifier.citationXU JINHUI (2021-08-10). FUNCTIONALIZATION OF ARYL CHLORIDES AND PYRIDINE N-oxides ENABLED BY ORGANOPHOTOCATALYSIS. ScholarBank@NUS Repository.
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/212678
dc.description.abstractIn this thesis, we have realized the functionalization of aryl chlorides and pyridine N-oxides by organophotocatalysis. First, we discovered that donor-acceptor cyanoarene-based fluorophores can undergo consecutive photoinduced electron transfer (ConPET) process to access catalysts with exceedingly high reducing power. This strategy enables to activate aryl chlorides with very negative reduction potentials for C-B, C-P, and C-C bond formations to furnish a broad scope of arylboronates, arylphosphonium salts, arylphosphonates, and spirocyclic cyclohexadienes. We also developed a method of visible-light-induced alkylation/acylation of pyridine N-oxides with alkynes via organophotocatalysis. The divergent alkylating or acylating products could easily achived by simply switching between anaerobic and aerobic conditions. Over all, these methods provide opportunities to achieve previous inaccessible reactivity and transformations, including late-stage pharmaceutical functionalization. Especially for the first project, it provides a platform to further explore and understand the design principles for more potent photocatalysts based on the ConPET process.
dc.language.isoen
dc.subjectorganophotocatalysis, photocatalysts,ConPET, pyridine N-oxides,aryl chlorides,borylation
dc.typeThesis
dc.contributor.departmentCHEMISTRY
dc.contributor.supervisorWu Jie
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY (FOS)
dc.identifier.orcid0000-0001-6832-3736
Appears in Collections:Ph.D Theses (Open)

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