Please use this identifier to cite or link to this item: https://doi.org/10.1111/acel.12842
Title: Dysregulated homeostatic pathways in sarcopenia among frail older adults
Authors: Ng, T.P. 
Lu, Y.
Choo, R.W.M.
Tan, C.T.Y.
Nyunt, M.S.Z. 
Gao, Q. 
Mok, E.W.H.
Larbi, A.
Keywords: anemia
blood biomarkers
cortisol
cytokines
DHEAS
glomerular
inflammation
insulin
leptin
muscle mass and function
testosterone
Issue Date: 2018
Publisher: Blackwell Publishing Ltd
Citation: Ng, T.P., Lu, Y., Choo, R.W.M., Tan, C.T.Y., Nyunt, M.S.Z., Gao, Q., Mok, E.W.H., Larbi, A. (2018). Dysregulated homeostatic pathways in sarcopenia among frail older adults. Aging Cell 17 (6) : e12842. ScholarBank@NUS Repository. https://doi.org/10.1111/acel.12842
Rights: Attribution 4.0 International
Abstract: Sarcopenia, a core feature of the physical frailty syndrome, is characterized by multisystem physiological dysregulation. No study has explored qualitatively the hierarchical network of relationships among different dysregulated pathways involved in the pathogenesis of sarcopenia. We used 40 blood biomarkers belonging to community-dwelling prefrail and frail older persons to derive measures of multiple physiological pathways, and structural equation modeling to generate path network models of the multisystem physiological dysregulations associated with muscle mass and function (MMF). Insulin–leptin signaling and energy regulation, anabolic sex steroid regulation (testosterone, leptin), and tissue oxygenation (hemoglobin, red cell count) appear to be primary mediating factors exerting direct influences on MMF. There was additionally secondary mediatory involvement of myocyte- and adipocyte-derived cytokines, hypothalamic pituitary adrenal (HPA) stress hormones (cortisol, DHEAS), glomerular function, and immune cell regulatory and inflammatory cytokines and glycoproteins. We conclude that within a hierarchical network of multisystem physiological dysregulations in sarcopenia, dysregulated anabolic and catabolic pathways via sex steroids and insulin–leptin dual signaling and tissue hypoxemia are primary physiological dysregulations responsible for sarcopenia and frailty. © 2018 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Source Title: Aging Cell
URI: https://scholarbank.nus.edu.sg/handle/10635/212528
ISSN: 1474-9718
DOI: 10.1111/acel.12842
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1111_acel_12842.pdf419.85 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

15
checked on May 14, 2022

Page view(s)

37
checked on May 12, 2022

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons