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Title: A Boltzmann-Tsallis approach towards cell survival curve in radiobiology
Authors: Tan, B.W.Q.
Tan, H.Q.
Chan, A.H. 
Issue Date: 2018
Publisher: INSPIRE
Citation: Tan, B.W.Q., Tan, H.Q., Chan, A.H. (2018). A Boltzmann-Tsallis approach towards cell survival curve in radiobiology. Proceedings - 48th International Symposium on Multiparticle Dynamics, ISMD 2018 : 9014. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: This paper outlines a phenomenological approach towards cell survival curve at low dose using tools of extensive Statistical Mechanics and nonextensive Statistical Mechanics. An Ising chain model is developed for the cell survival curve and the canonical ensemble formalism based on Boltzmann Gibbs statistic and Tsallis statistic is presented. The resulting cell survival curve shows excellent agreement with the experimental data and the physical parameters from our Tsallis model (N’, q) can be shown to provide clear classification between healthy and cancerous cells. In this paper, we also provides possible biophysical interpretation to the (N’, q) parameters where N’ is representative of the amount of repairable DNA content in the nucleus and q represents the degree of correlation in DNA damage. Overall, this is the first time a Statistical Mechanics approach is used in Radiobiology, and could present a new perspective. © The Authors, published by EDP Sciences.
Source Title: Proceedings - 48th International Symposium on Multiparticle Dynamics, ISMD 2018
DOI: 10.1051/epjconf/201920609014
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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