Please use this identifier to cite or link to this item: https://doi.org/10.3389/fphys.2019.00158
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dc.titleRelationships between ion channels, mitochondrial functions and inflammation in human aging
dc.contributor.authorStrickland, M.
dc.contributor.authorYacoubi-Loueslati, B.
dc.contributor.authorBouhaouala-Zahar, B.
dc.contributor.authorPender, S.L.F.
dc.contributor.authorLarbi, A.
dc.date.accessioned2021-12-29T04:39:51Z
dc.date.available2021-12-29T04:39:51Z
dc.date.issued2019
dc.identifier.citationStrickland, M., Yacoubi-Loueslati, B., Bouhaouala-Zahar, B., Pender, S.L.F., Larbi, A. (2019). Relationships between ion channels, mitochondrial functions and inflammation in human aging. Frontiers in Physiology 10 (MAR) : 158. ScholarBank@NUS Repository. https://doi.org/10.3389/fphys.2019.00158
dc.identifier.issn1664042X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/212366
dc.description.abstractAging is often associated with a loss of function. We believe aging to be more an adaptation to the various, and often continuous, stressors encountered during life in order to maintain overall functionality of the systems. The maladaptation of a system during aging may increase the susceptibility to diseases. There are basic cellular functions that may influence and/or are influenced by aging. Mitochondrial function is amongst these. Their presence in almost all cell types makes of these valuable targets for interventions to slow down or even reserve signs of aging. In this review, the role of mitochondria and essential physiological regulators of mitochondria and cellular functions, ion channels, will be discussed in the context of human aging. The origins of inflamm-aging, associated with poor clinical outcomes, will be linked to mitochondria and ion channel biology. © 2019 Strickland, Yacoubi-Loueslati, Bouhaouala-Zahar, Pender and Larbi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.subjectAging
dc.subjectCellular senescence
dc.subjectInflammation
dc.subjectIon channels
dc.subjectMitochondria
dc.typeArticle
dc.contributor.departmentDEPT OF MICROBIOLOGY & IMMUNOLOGY
dc.description.doi10.3389/fphys.2019.00158
dc.description.sourcetitleFrontiers in Physiology
dc.description.volume10
dc.description.issueMAR
dc.description.page158
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