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Title: Relationships between ion channels, mitochondrial functions and inflammation in human aging
Authors: Strickland, M.
Yacoubi-Loueslati, B.
Bouhaouala-Zahar, B.
Pender, S.L.F.
Larbi, A. 
Keywords: Aging
Cellular senescence
Ion channels
Issue Date: 2019
Publisher: Frontiers Media S.A.
Citation: Strickland, M., Yacoubi-Loueslati, B., Bouhaouala-Zahar, B., Pender, S.L.F., Larbi, A. (2019). Relationships between ion channels, mitochondrial functions and inflammation in human aging. Frontiers in Physiology 10 (MAR) : 158. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Aging is often associated with a loss of function. We believe aging to be more an adaptation to the various, and often continuous, stressors encountered during life in order to maintain overall functionality of the systems. The maladaptation of a system during aging may increase the susceptibility to diseases. There are basic cellular functions that may influence and/or are influenced by aging. Mitochondrial function is amongst these. Their presence in almost all cell types makes of these valuable targets for interventions to slow down or even reserve signs of aging. In this review, the role of mitochondria and essential physiological regulators of mitochondria and cellular functions, ion channels, will be discussed in the context of human aging. The origins of inflamm-aging, associated with poor clinical outcomes, will be linked to mitochondria and ion channel biology. © 2019 Strickland, Yacoubi-Loueslati, Bouhaouala-Zahar, Pender and Larbi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Source Title: Frontiers in Physiology
ISSN: 1664042X
DOI: 10.3389/fphys.2019.00158
Rights: Attribution 4.0 International
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