Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers11081176
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dc.titleAdaptive responses as mechanisms of resistance to braf inhibitors in melanoma
dc.contributor.authorSaei, A.
dc.contributor.authorEichhorn, P.J.A.
dc.date.accessioned2021-12-29T04:33:43Z
dc.date.available2021-12-29T04:33:43Z
dc.date.issued2019
dc.identifier.citationSaei, A., Eichhorn, P.J.A. (2019). Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma. Cancers 11 (8) : 1176. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers11081176
dc.identifier.issn20726694
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/212283
dc.description.abstractThe introduction of v-raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors in melanoma patients with BRAF (V600E) mutations has demonstrated significant clinical benefits. However, rarely do tumours regress completely. Frequently, the reason for this is that therapies targeting specific oncogenic mutations induce a number of intrinsic compensatory mechanisms, also known as adaptive responses or feedback loops, that enhance the pro-survival and pro-proliferative capacity of a proportion of the original tumour population, thereby resulting in tumour progression. In this review we will summarize the known adaptive responses that limit BRAF mutant therapy and discuss potential novel combinatorial therapies to overcome resistance. © 2019 by the authors.
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.subjectAdaptive responses
dc.subjectBRAF
dc.subjectMelanoma
dc.subjectResistance
dc.typeReview
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.description.doi10.3390/cancers11081176
dc.description.sourcetitleCancers
dc.description.volume11
dc.description.issue8
dc.description.page1176
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