Please use this identifier to cite or link to this item: https://doi.org/10.3390/biom9110735
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dc.titleRole of reactive oxygen species in cancer progression: Molecular mechanisms and recent advancements
dc.contributor.authorAggarwal, V.
dc.contributor.authorTuli, H.S.
dc.contributor.authorVarol, A.
dc.contributor.authorThakral, F.
dc.contributor.authorYerer, M.B.
dc.contributor.authorSak, K.
dc.contributor.authorVarol, M.
dc.contributor.authorJain, A.
dc.contributor.authorKhan, M.A.
dc.contributor.authorSethi, G.
dc.date.accessioned2021-12-29T04:32:22Z
dc.date.available2021-12-29T04:32:22Z
dc.date.issued2019
dc.identifier.citationAggarwal, V., Tuli, H.S., Varol, A., Thakral, F., Yerer, M.B., Sak, K., Varol, M., Jain, A., Khan, M.A., Sethi, G. (2019). Role of reactive oxygen species in cancer progression: Molecular mechanisms and recent advancements. Biomolecules 9 (11) : 735. ScholarBank@NUS Repository. https://doi.org/10.3390/biom9110735
dc.identifier.issn2218273X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/212266
dc.description.abstractReactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate regulation between the silver lining of low and high ROS concentration mediated effects. Interestingly, ROS also dynamically influences the tumor microenvironment and is known to initiate cancer angiogenesis, metastasis, and survival at different concentrations. At moderate concentration, ROS activates the cancer cell survival signaling cascade involving mitogen-activated protein kinase/extracellular signal-regulated protein kinases 1/2 (MAPK/ERK1/2), p38, c-Jun N-terminal kinase (JNK), and phosphoinositide-3-kinase/ protein kinase B (PI3K/Akt), which in turn activate the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B), matrix metalloproteinases (MMPs), and vascular endothelial growth factor (VEGF). At high concentrations, ROS can cause cancer cell apoptosis. Hence, it critically depends upon the ROS levels, to either augment tumorigenesis or lead to apoptosis. The major issue is targeting the dual actions of ROS effectively with respect to the concentration bias, which needs to be monitored carefully to impede tumor angiogenesis and metastasis for ROS to serve as potential therapeutic targets exogenously/endogenously. Overall, additional research is required to comprehend the potential of ROS as an effective anti-tumor modality and therapeutic target for treating malignancies. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.subjectAngiogenesis
dc.subjectInflammation
dc.subjectMetastasis
dc.subjectMiRNA
dc.subjectOxidative stress
dc.subjectReactive oxygen species (ROS)
dc.typeReview
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.description.doi10.3390/biom9110735
dc.description.sourcetitleBiomolecules
dc.description.volume9
dc.description.issue11
dc.description.page735
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