Please use this identifier to cite or link to this item:
Title: Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis.
Authors: Rauschmeier, René
Reinhardt, Annika
Gustafsson, Charlotte
Glaros, Vassilis
Artemov, Artem V
Dunst, Josefine
Taneja, Reshma 
Adameyko, Igor
Månsson, Robert
Busslinger, Meinrad
Kreslavsky, Taras
Issue Date: 7-Feb-2022
Publisher: Rockefeller University Press
Citation: Rauschmeier, René, Reinhardt, Annika, Gustafsson, Charlotte, Glaros, Vassilis, Artemov, Artem V, Dunst, Josefine, Taneja, Reshma, Adameyko, Igor, Månsson, Robert, Busslinger, Meinrad, Kreslavsky, Taras (2022-02-07). Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis.. J Exp Med 219 (2). ScholarBank@NUS Repository.
Abstract: The generation of high-affinity antibodies against pathogens and vaccines requires the germinal center (GC) reaction, which relies on a complex interplay between specialized effector B and CD4 T lymphocytes, the GC B cells and T follicular helper (TFH) cells. Intriguingly, several positive key regulators of the GC reaction are common for both cell types. Here, we report that the transcription factor Bhlhe40 is a crucial cell-intrinsic negative regulator affecting both the B and T cell sides of the GC reaction. In activated CD4 T cells, Bhlhe40 was required to restrain proliferation, thus limiting the number of TFH cells. In B cells, Bhlhe40 executed its function in the first days after immunization by selectively restricting the generation of the earliest GC B cells but not of early memory B cells or plasmablasts. Bhlhe40-deficient mice with progressing age succumbed to a B cell lymphoma characterized by the accumulation of monoclonal GC B-like cells and polyclonal TFH cells in various tissues.
Source Title: J Exp Med
ISSN: 00221007
DOI: 10.1084/jem.20211406
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Taras.pdfAccepted version60.57 MBAdobe PDF




checked on Sep 30, 2022

Page view(s)

checked on Oct 6, 2022


checked on Oct 6, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.