Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.19-26777
Title: Variation of peripapillary scleral shape with age
Authors: Tun, T.A. 
Wang, X. 
Baskaran, M.
Nongpiur, M.E.
Tham, Y.-C.
Perera, S.A.
Strouthidis, N.G.
Aung, T. 
Cheng, C.-Y. 
Girard, M.J.A.
Keywords: Age
Choroidal thickness
Laminar depth
Peripapillary sclera
Issue Date: 2019
Publisher: Association for Research in Vision and Ophthalmology Inc.
Citation: Tun, T.A., Wang, X., Baskaran, M., Nongpiur, M.E., Tham, Y.-C., Perera, S.A., Strouthidis, N.G., Aung, T., Cheng, C.-Y., Girard, M.J.A. (2019). Variation of peripapillary scleral shape with age. Investigative Ophthalmology and Visual Science 60 (10) : 3275-3282. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.19-26777
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: PURPOSE. To define the shape of the anterior surface of the peripapillary sclera (PPS) and evaluate its relationship with age and ocular determinants in a population-based Chinese cohort. METHODS. The optic nerve heads of 619 healthy Chinese subjects were imaged with spectral-domain optical coherence tomography. To assess the shape of the PPS/Bruch’s membrane (BM), we measured the angle between a line parallel to the nasal anterior PPS/BM boundary and one parallel to the temporal side. A negative value indicated that the PPS/BM followed an inverted v-shaped configuration (peak pointing toward the vitreous), whereas a positive value indicated that it followed a v-shaped configuration (peak pointing toward the orbital tissues). A linear regression model was used to evaluate the relationship between the PPS angle and other ocular parameters. RESULTS. The mean PPS angle was 3.68° ±6.73° and the BM angle was 9.69° ±5.05°. The PPS angle increased on average by 0.233 deg/y. A v-shaped PPS was significantly associated with age (? = 0.087, P = 0.004), peripapillary choroidal thickness (? = 0.479, P < 0.001), lamina cribrosa depth (? = 0.307, P < 0.001), and BM angle (? = 0.487, P < 0.001) after adjusting for best corrected visual acuity, central corneal thickness, and axial length. CONCLUSIONS. The anterior surface of PPS of an elderly adult population had a v-shaped configuration and was more pronounced with increasing age, thin peripapillary choroid, and a deep cup. Such a change in shape with age could have an impact on the biomechanical environment of the optic nerve head. © 2019 The Authors.
Source Title: Investigative Ophthalmology and Visual Science
URI: https://scholarbank.nus.edu.sg/handle/10635/212110
ISSN: 0146-0404
DOI: 10.1167/iovs.19-26777
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1167_iovs_19-26777.pdf815.71 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

8
checked on Aug 8, 2022

Page view(s)

51
checked on Aug 4, 2022

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons