Please use this identifier to cite or link to this item: https://doi.org/10.5217/ir.2018.00099
Title: Health-related quality of life of patients with inflammatory bowel disease in Singapore
Authors: Ho, P.Y.M.
Hu, W.
Lee, Y.Y.
Gao, C.
Tan, Y.Z.
Cheen, H.H.
Wee, H.L. 
Lim, T.G.
Ong, W.C.
Keywords: Crohn's disease
Health-related quality of life
Inflammatory bowel disease
Singapore
Ulcerative colitis
Issue Date: 2019
Publisher: Korean Association for the Study of Intestinal Diseases
Citation: Ho, P.Y.M., Hu, W., Lee, Y.Y., Gao, C., Tan, Y.Z., Cheen, H.H., Wee, H.L., Lim, T.G., Ong, W.C. (2019). Health-related quality of life of patients with inflammatory bowel disease in Singapore. Intestinal Research 17 (1) : 107-118. ScholarBank@NUS Repository. https://doi.org/10.5217/ir.2018.00099
Rights: Attribution-NonCommercial 4.0 International
Abstract: Background/Aims: Inflammatory bowel disease (IBD) is associated with considerable impairment of patients' health-related quality of life (HRQoL). Knowledge of factors that significantly affect IBD patients' HRQoL can contribute to better patient care. However, the HRQoL of IBD patients in non-Western countries are limited. Hence, we assessed the HRQoL of Singaporean IBD patients and identified its determinants. Methods: A prospective, cross-sectional study was conducted at Singapore General Hospital outpatient IBD Centre. The HRQoL of IBD patients was assessed using the short IBD questionnaire (SIBDQ), Short Form-36 physical and mental component summary (SF-36 PCS/MCS) and EuroQol 5-dimensions 3-levels (EQ-5D-3L) and visual analogue scale (VAS). Independent samples t-test was used to compare HRQoL between Crohn's disease (CD) and ulcerative colitis (UC). Determinants of HRQoL were identified through multiple linear regression. Results: A total of 195 IBD patients (103 UC, 92 CD) with a mean disease duration of 11.2 years were included. There was no significant difference in HRQoL between patients with UC and CD. Factors that significantly worsened HRQoL were presence of active disease (b=-6.293 [SIBDQ], -9.409 [PCS], -9.743 [MCS], -7.254 [VAS]), corticosteroids use (b=-7.392 [SIBDQ], -10.390 [PCS], -8.827 [MCS]), poor medication adherence (b=-4.049 [SIBDQ], -1.320 [MCS], -8.961 [VAS]), presence of extraintestinal manifestations (b=-13.381 [PCS]), comorbidities (b=-4.531 [PCS]), non-employment (b=-9.738 [MCS], -0.104 [EQ-5D-3L]) and public housing (b=-8.070 [PCS], -9.207 [VAS]). Conclusions: The HRQoL is impaired in this Asian cohort of IBD. The magnitude of HRQoL impairment was similar in UC and CD. Clinical characteristics were better determinants of patients' HRQoL than socio-demographic factors. Recognizing the factors that impact patients' HRQoL would improve the holistic management of IBD patients. © 2019, Korean Association for the Study of Intestinal Diseases. All rights reserved.
Source Title: Intestinal Research
URI: https://scholarbank.nus.edu.sg/handle/10635/210919
ISSN: 15989100
DOI: 10.5217/ir.2018.00099
Rights: Attribution-NonCommercial 4.0 International
Appears in Collections:Elements
Students Publications
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_5217_ir_2018_00099.pdf478.02 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

17
checked on Jan 26, 2023

Page view(s)

102
checked on Jan 26, 2023

Download(s)

1
checked on Jan 26, 2023

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons