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Title: Generation of Drosophila sisRNAs by Independent Transcription from Cognate Introns
Authors: Jia Ng, S.S.
Zheng, R.T.
Osman, I.
Pek, J.W. 
Keywords: Developmental Biology
Molecular Biology
Molecular Mechanism of Gene Regulation
Issue Date: 2018
Publisher: Elsevier Inc.
Citation: Jia Ng, S.S., Zheng, R.T., Osman, I., Pek, J.W. (2018). Generation of Drosophila sisRNAs by Independent Transcription from Cognate Introns. iScience 4 : 68-75. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Molecular Biology; Molecular Mechanism of Gene Regulation; Developmental Biology; Transcriptomics © 2018 The Author(s)Although stable intronic sequence RNAs (sisRNAs)are conserved in plants and animals, their functional significance is still unclear. We identify a pool of polyadenylated maternally deposited sisRNAs in Drosophila melanogaster. These sisRNAs can be generated by independent transcription from the cognate introns. The ovary-specific poly(A)polymerase Wispy mediates the polyadenylation of maternal sisRNAs and confers their stability as maternal transcripts. A developmentally regulated sisRNA sisR-3 represses the expression of a long noncoding RNA CR44148 and is required during development. Our results expand the pool of sisRNAs and suggest that sisRNAs perform regulatory functions during development in Drosophila. © 2018 The Author(s)
Source Title: iScience
ISSN: 25890042
DOI: 10.1016/j.isci.2018.05.010
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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